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Published on: July 16, 2016
Sweet's syndrome: a study of 23 cases.
Adma Silva de Lima Wojcik1, Fátima Satomi Nishimori, Jesus Rodriguez Santamaría
1Dermatology Service of the Clinics Hospital, Federal University of Parana (UFRP) - Curitiba (PR), Brazil. adma_lima@ibest.com.br
Sweet's syndrome, a rare neutrophilic dermatosis, presents with painful skin lesions and fever. This study found its characteristics align with existing literature, highlighting a significant association with neoplasia, especially hematologic malignancies.
Area of Science:
- Dermatology
- Rheumatology
- Oncology
Background:
- Sweet's syndrome, or acute febrile neutrophilic dermatosis, is a rare condition.
- It is characterized by painful skin lesions, fever, and elevated white blood cell counts.
- Corticosteroids are an effective treatment.
Purpose of the Study:
- To analyze clinical, laboratory, and epidemiological features of Sweet's syndrome cases.
- To compare findings with existing medical literature.
- To assess the association with underlying conditions, particularly malignancies.
Main Methods:
- Retrospective epidemiological study of 23 patients diagnosed with Sweet's syndrome.
- Data collected from March 1995 to July 2009.
- Analysis included lesion characteristics, systemic manifestations, associated conditions, and laboratory markers like leukocyte count and ESR.
Main Results:
- Patient age ranged from 2 to 75 years, with a higher prevalence in females.
- Lesions predominantly affected the trunk and upper limbs.
- Common systemic symptoms included fever, arthralgia, myalgia, conjunctivitis, and arthritis; respiratory infections were frequent triggers. Neoplasia, particularly hematologic, was present in 30% of patients.
Conclusions:
- Clinical and epidemiological data align with current literature.
- A significant association with underlying malignant diseases, especially hematologic ones, was observed.
- Emphasizes the need for accurate diagnosis, thorough investigation, and diligent patient follow-up due to the high prevalence of associated cancers.
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