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Cutaneous manifestations in end-stage renal disease
Omar Lupi1, Ludimila Rezende, Mariane Zangrando
1Dermatology Service of the General Polyclinic of Rio de Janeiro and at the Internal Medicine Service (10th Ward) - School of Medicine and Surgery, Federal University of Rio de Janeiro State (UNIRIO) - Rio de Janeiro (RJ), Brazil.
Abstract:
The prevalence of chronic kidney disease has increased over the last years. The effects of this disease are complex and may lead to dysfunction of multiple organs, including the skin, with most patients presenting with at least one dermatologic alteration. Sometimes these symptoms can be the first clear sign of kidney disease. This article discusses the skin manifestations related to severe renal impairment or end-stage renal disease (ESRD), which are divided into nonspecific and specific, and reviews the clinical features, etiopathogenesis and therapeutic options for these dermatoses. Early recognition and treatment reduce morbidity and improve these patients' quality of life.
Insights
Chronic kidney disease (CKD) increasingly affects multiple organs, notably the skin. Recognizing dermatologic symptoms can be an early indicator of CKD, improving patient outcomes.
Area of Science:
- Nephrology
- Dermatology
Background:
- Chronic kidney disease (CKD) prevalence is rising globally.
- CKD complications extend to skin health, with most patients experiencing dermatologic issues.
- Skin symptoms can be early indicators of kidney dysfunction.
Purpose of the Study:
- To review skin manifestations in severe renal impairment and end-stage renal disease (ESRD).
- To discuss clinical features, causes, and treatments for these kidney-related skin conditions.
Main Methods:
- Literature review of dermatologic manifestations in CKD patients.
- Categorization of skin issues into nonspecific and specific types.
- Analysis of clinical presentation, pathogenesis, and therapeutic strategies.
Main Results:
- Patients with severe kidney disease frequently present with diverse skin alterations.
- These dermatoses are classified as nonspecific or specific to the renal condition.
- Understanding these manifestations is key for diagnosis and management.
Conclusions:
- Early identification of skin symptoms in CKD is crucial.
- Effective management of dermatologic issues can enhance patient quality of life.
- Timely treatment reduces disease-related complications.
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