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Integrins

Integrins

Animal and protozoan cells do not have cell walls to help maintain shape and provide structural stability. Instead, these eukaryotic cells secrete a sticky mass of carbohydrates and proteins into the spaces between adjacent cells. This network of proteins and molecules is called an extracellular matrix or ECM.
Some ECM proteins assemble into a basement membrane to which the remaining components adhere. Proteoglycans typically form the bulk of the ECM while fibrous proteins, like collagen,...

Renal Corpuscle

Renal Corpuscle

The glomerulus and Bowman's capsule are two essential components of the nephron, which is the functional unit of the kidney. These microscopic structures play a critical role in the process of blood filtration to produce urine.
Glomerulus: Structure and Function
The glomerulus is a tiny, intricate network of capillaries located at the beginning of the nephron. It's enveloped by the Bowman's capsule and receives its blood supply from an afferent arteriole, which divides into numerous capillaries...

Renal Tubule and Collecting Duct

Renal Tubule and Collecting Duct

The renal tubule is divided into three parts: the proximal convoluted tubule (PCT), the Loop of Henle (LOH), and the distal convoluted tubule (DCT).
Proximal Convoluted Tubule (PCT):
The PCT is the initial segment of the renal tubule, extending from the Bowman's capsule that encloses the glomerulus. Its convoluted structure and microvilli-lined cells increase the surface area for reabsorption. The PCT reabsorbs glucose, amino acids, sodium, and water from the filtrate, ensuring essential...

Internal Anatomy of the Kidney

Internal Anatomy of the Kidney

The kidneys are essential organs in the human body, performing a myriad of tasks that maintain homeostasis and overall health.
Anatomical Position and Dimensions
The kidneys are retroperitoneal organs positioned against the posterior abdominal wall on either side of the spine, roughly between the twelfth thoracic and third lumbar vertebrae. Each kidney is typically 10-12 cm long, 5-6 cm wide, and 3-4 cm thick, weighing about 150 grams.
Renal Cortex
The outermost region of the kidney is the...

Kidney Structure

Kidney Structure

The kidneys are two large bean-shaped organs located in the upper abdomen. They filter the blood several times a day to remove toxins and rebalance water and electrolytes of the circulatory system via the renal veins. The kidneys receive blood directly from the heart via the renal arteries. These arteries enter the kidney at the hilum, the concave surface of the bean, where they branch and divide into smaller vessels and capillaries.

Intracellular Signaling Affects Focal Adhesions

Intracellular Signaling Affects Focal Adhesions

Integrins act both as extracellular input receivers and as intracellular processing activators. As their name suggests, integrins are entirely integrated into the membrane structure. Their hydrophobic membrane-spanning regions interact with the phospholipid bilayer's hydrophobic region. These membrane receptors provide extracellular attachment sites for effectors like hormones and growth factors. They activate intracellular response cascades when their effectors are bound and active.
Some...

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Related Experiment Video

Updated: Jun 1, 2026

In Utero Intra-cardiac Tomato-lectin Injections on Mouse Embryos to Gauge Renal Blood Flow

In Utero Intra-cardiac Tomato-lectin Injections on Mouse Embryos to Gauge Renal Blood Flow

Published on: February 4, 2015

Integrins in renal development.

Sijo Mathew¹, Xiwu Chen, Ambra Pozzi

¹Department of Medicine (Division of Nephrology), Vanderbilt University Medical Center, Nashville, TN, USA.

Pediatric Nephrology (Berlin, Germany)

|May 24, 2011

Summary

This summary is machine-generated.

This review explores how integrins, crucial cell receptors, regulate kidney development by mediating cell-extracellular matrix interactions during the formation of the ureteric bud and metanephric mesenchyme.

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Area of Science:

Developmental Biology
Cell Biology
Nephrology

Background:

Kidney development involves intricate interactions between the ureteric bud and metanephric mesenchyme.
These interactions are vital for forming the collecting system and nephrons, respectively.
Cellular communication with the extracellular matrix is a key mediator in this complex process.

Purpose of the Study:

To review the role of integrins in regulating renal development.
To highlight how integrins facilitate communication between cells and the extracellular matrix during kidney organogenesis.

Main Methods:

Literature review focusing on integrin function in renal development.
Analysis of existing research on cell-matrix interactions in kidney embryogenesis.

Main Results:

Integrins act as primary receptors for extracellular matrix proteins.
These receptors are critical for mediating the signaling pathways that govern kidney development.
Integrin activity influences the differentiation and organization of renal structures.

Conclusions:

Integrins play a fundamental role in orchestrating kidney development.
Understanding integrin-mediated processes offers insights into congenital kidney diseases and potential therapeutic targets.