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Published on: December 3, 2019
[Study on antineoplastic effect of earthworm coelomic fluid in vitro]
Jian-Hua Wang1, Tao Guan, Xiao-Yuan Wang
1Department of Life Sciences and Bioengineering, Beijing University of Technology, Beijing 100022, China.
Objective:
To explore the antineoplastic effect in vitro of earthworm coelomic fluid (ECF)on growth inhibition and its mechanism for the tumor cell lines Siha, SW480, Colo205 and PC12.
Methods:
MTT colorimetric assay, flow cytometry and morphological analysis were used to test its antitumor activity on tumor cell lines and normal cell line Cos7 in vitro.
Results:
ECF can inhibit the cell growth of Siha, SW480, Colo205, PC12 and Cos7. But different tumor cell lines showed different sensitivity.
Conclusion:
EFC can significantly inhibit the proliferation of tumor cells in vitro by inducing tumor cells apoptosis.
