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[Clinical value of CD64 expression in adults with measles complicating bacterial pneumonia]

Jia-Liang Tang1, Wen-Fang Xu, Yong Wu

  • 1The Dou-Men People's Hospital of Shaoxin, Zhejiang 312000, China. tangjl1967@yahoo.com.cn

Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi = Zhonghua Shiyan He Linchuang Bingduxue Zazhi = Chinese Journal of Experimental and Clinical Virology
|May 25, 2011
PubMed
Abstract

Insights

Neutrophil CD64 expression is a superior early diagnostic marker for bacterial pneumonia complicating measles compared to C-reactive protein (CRP). This finding aids in distinguishing bacterial from viral pneumonia in measles patients.

Area of Science:

  • Immunology
  • Infectious Diseases
  • Clinical Diagnostics

Context:

  • Measles can lead to secondary bacterial or viral pneumonia.
  • Accurate differentiation between bacterial and viral pneumonia is crucial for appropriate treatment.
  • Neutrophil CD64 expression is an inflammatory marker.

Purpose:

  • To evaluate the clinical utility of peripheral blood neutrophil CD64 expression in diagnosing bacterial pneumonia complicating measles.
  • To compare the diagnostic value of CD64 with C-reactive protein (CRP) and white blood cell (WBC) count.

Summary:

  • Neutrophil CD64 expression was significantly higher in patients with measles complicating bacterial pneumonia during the eruptive stage compared to the recovery stage or viral pneumonia.
  • CD64 demonstrated good sensitivity (78.12%) and specificity (76.19%) for diagnosing bacterial pneumonia, with a positive correlation with CRP.
  • CD64 expression is a valuable early diagnostic marker for bacterial pneumonia in measles patients, outperforming CRP.

Impact:

  • Provides a more accurate and earlier diagnostic tool for bacterial pneumonia in measles cases.
  • Facilitates timely and targeted antibiotic therapy, potentially improving patient outcomes.
  • Contributes to a better understanding of inflammatory markers in complex infectious diseases.

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