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International Expert Consensus and Recommendations for Neonatal Pneumothorax Ultrasound Diagnosis and Ultrasound-guided Thoracentesis Procedure
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Published on: March 12, 2020

Risk factors for bronchopulmonary dysplasia in neonates born at ≤ 1500 g (1999-2009)

Hongshan Zhang1, Jianpei Fang, Haobin Su

  • 1Department of Pediatrics, Second Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China. ywh1998@21cn.com

Pediatrics International : Official Journal of the Japan Pediatric Society
|May 25, 2011
PubMed

Insights

Bronchopulmonary dysplasia (BPD) affects nearly half of very low-birthweight infants despite improved perinatal care. Key risk factors include early gestational age, maternal chorioamnionitis, pneumonia, and multiple blood transfusions.

Area of Science:

  • Neonatology
  • Perinatal Medicine
  • Pediatric Pulmonology

Background:

  • Despite advances in perinatal care, the incidence of bronchopulmonary dysplasia (BPD) remains high in very low-birthweight (VLBW) infants.
  • Improving survival rates for VLBW infants necessitates understanding and mitigating BPD risk factors.

Purpose of the Study:

  • To identify perinatal risk factors associated with the development of BPD in neonates weighing ≤ 1500 grams.

Main Methods:

  • A retrospective analysis was conducted on data from neonates born at ≤ 1500 g between 1999 and 2009.
  • Data were collected from the neonatal intensive care unit (NICU) of the Second Affiliated Hospital of Sun Yat-Sen University in Guangzhou, China.

Main Results:

  • The study included 149 preterm infants born at ≤ 1500 g, with a 48.3% incidence of BPD and a 77.8% survival rate at 28 days.
  • Logistic regression identified gestational age ≤ 30 weeks, maternal chorioamnionitis, ventilation-associated pneumonia, and more than three blood transfusions as significant risk factors for BPD.

Conclusions:

  • The study provides clinical evidence for significant perinatal risk factors contributing to BPD in VLBW neonates.
  • Identifying these risk factors can inform further research and clinical strategies to reduce BPD incidence and improve VLBW infant outcomes.
Abstract

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