Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Circadian Rhythms and Gene Regulation02:19

Circadian Rhythms and Gene Regulation

The biological clock is involved in many aspects of regulating complex physiology in all animals. It was in 1935 when German zoologists, Hans Kalmus and Erwin Bünning, discovered the existence of circadian rhythm in Drosophila melanogaster. However, the internal molecular mechanisms behind the circadian clock remained a mystery until 1984, when Jeffrey C. Hall, Michael Rosbash, and Michael W. Young discovered the expression of the Per gene oscillating over a 24-hour cycle. In subsequent years,...
Circadian Rhythms and Gene Regulation02:19

Circadian Rhythms and Gene Regulation

The biological clock is involved in many aspects of regulating complex physiology in all animals. It was in 1935 when German zoologists, Hans Kalmus and Erwin Bünning, discovered the existence of circadian rhythm in Drosophila melanogaster. However, the internal molecular mechanisms behind the circadian clock remained a mystery until 1984, when Jeffrey C. Hall, Michael Rosbash, and Michael W. Young discovered the expression of the Per gene oscillating over a 24-hour cycle. In subsequent years,...
Oscillations In An LC Circuit01:30

Oscillations In An LC Circuit

An idealized LC circuit of zero resistance can oscillate without any source of emf by shifting the energy stored in the circuit between the electric and magnetic fields. In such an LC circuit, if the capacitor contains a charge q before the switch is closed, then all the energy of the circuit is initially stored in the electric field of the capacitor. This energy is given by
Feedback Regulation of Calcium Concentration01:27

Feedback Regulation of Calcium Concentration

Calcium is an essential signaling molecule required for various cellular functions. Calcium pumps and ion channels on cell and organellar membranes, such as those on the endoplasmic reticulum (ER), regulate calcium concentrations inside the cell. They remain closed, keeping the cytosolic calcium levels low at a resting state.
Various transmembrane receptors, such as G protein-coupled receptors (GPCRs), elicit a response to extracellular signals by increasing cytosolic calcium. Activated GPCRs...
Forced Oscillations01:06

Forced Oscillations

When an oscillator is forced with a periodic driving force, the motion may seem chaotic. The motions of such oscillators are known as transients. After the transients die out, the oscillator reaches a steady state, where the motion is periodic, and the displacement is determined.
Damped Oscillations01:07

Damped Oscillations

In the real world, oscillations seldom follow true simple harmonic motion. A system that continues its motion indefinitely without losing its amplitude is termed undamped. However, friction of some sort usually dampens the motion, so it fades away or needs more force to continue. For example, a guitar string stops oscillating a few seconds after being plucked. Similarly, one must continually push a swing to keep a child swinging on a playground.
Although friction and other non-conservative...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Segmentation of the parasagittal dura mater on multi-center 3D-FLAIR MRI.

NeuroImage·2026
Same author

<i>Schistosoma japonicum</i> Worms Alter the miRNA Expression Profile of Hepatic Stellate Cells with Potential Implications for Liver Fibrosis and Hepatocellular Carcinoma.

Tropical medicine and infectious disease·2026
Same author

Epigenetic compartmentalization of mitotic chromosomes by phase-separation-driven repulsion between WDR5 and the chromosomal passenger complex.

Nature communications·2026
Same author

Theory of chromosome structural dynamics by processive loop extrusion.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same author

Surface Tension of Acid Aqueous Solutions: An Analytical Theory.

The journal of physical chemistry. B·2026
Same author

[Relationship between adolescent internet addiction and depressive symptoms: A longitudinal study based on a cross-lagged panel network models].

Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences·2026

Related Experiment Video

Updated: Jun 1, 2026

Recording and Analysis of Circadian Rhythms in Running-wheel Activity in Rodents
05:46

Recording and Analysis of Circadian Rhythms in Running-wheel Activity in Rodents

Published on: January 24, 2013

Internal noise enhanced oscillation in a delayed circadian pacemaker.

Ruiting Zhang1, Tiejun Xiao, Zhonghuai Hou

  • 1Hefei National Laboratory for Physical Sciences at Microscales, University of Science and Technology of China, Anhui, China.

Biophysical Chemistry
|May 25, 2011
PubMed
Summary

Internal noise can trigger circadian oscillations in systems with time delays, even below critical thresholds. The study quantifies this phenomenon using signal-to-noise ratio (SNR) to define effective oscillations.

More Related Videos

Parallel Measurement of Circadian Clock Gene Expression and Hormone Secretion in Human Primary Cell Cultures
06:53

Parallel Measurement of Circadian Clock Gene Expression and Hormone Secretion in Human Primary Cell Cultures

Published on: November 11, 2016

In Vitro Bioluminescence Assay to Characterize Circadian Rhythm in Mammary Epithelial Cells
11:56

In Vitro Bioluminescence Assay to Characterize Circadian Rhythm in Mammary Epithelial Cells

Published on: September 28, 2017

Related Experiment Videos

Last Updated: Jun 1, 2026

Recording and Analysis of Circadian Rhythms in Running-wheel Activity in Rodents
05:46

Recording and Analysis of Circadian Rhythms in Running-wheel Activity in Rodents

Published on: January 24, 2013

Parallel Measurement of Circadian Clock Gene Expression and Hormone Secretion in Human Primary Cell Cultures
06:53

Parallel Measurement of Circadian Clock Gene Expression and Hormone Secretion in Human Primary Cell Cultures

Published on: November 11, 2016

In Vitro Bioluminescence Assay to Characterize Circadian Rhythm in Mammary Epithelial Cells
11:56

In Vitro Bioluminescence Assay to Characterize Circadian Rhythm in Mammary Epithelial Cells

Published on: September 28, 2017

Area of Science:

  • * Systems Biology
  • * Biophysics
  • * Chronobiology

Background:

  • * Circadian rhythms are endogenous biological processes crucial for health.
  • * Time delays and internal noise are inherent factors influencing biological oscillators.
  • * Understanding their interplay is key to deciphering circadian dynamics.

Purpose of the Study:

  • * To investigate the impact of internal noise on delayed circadian oscillators.
  • * To quantify noise-induced oscillations and define effective stochastic oscillations.
  • * To analyze the influence of system parameters on oscillation dynamics.

Main Methods:

  • * Utilized chemical Langevin equations for stochastic modeling.
  • * Employed stochastic normal form theory for analytical insights.
  • * Performed numerical simulations to validate theoretical findings.

Main Results:

  • * Internal noise can induce oscillations even when delay time is below the deterministic bifurcation point.
  • * Signal-to-noise ratio (SNR) effectively characterizes noise-induced oscillations.
  • * Effective oscillation range (Δτ(EO)) exhibits a bell-shaped dependence on noise intensity and is influenced by protein decay rates.

Conclusions:

  • * Internal noise plays a significant role in generating circadian oscillations in delayed systems.
  • * SNR provides a quantitative measure for effective stochastic oscillations.
  • * System parameters like decay rates critically modulate noise-induced oscillations, offering insights into circadian rhythm regulation.