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Updated: Sep 4, 2026

Identification of Cyclin-dependent Kinase 1 Specific Phosphorylation Sites by an In Vitro Kinase Assay
Published on: May 3, 2018
Association of type I phosphatidylinositol kinase activity with mutationally activated forms of human pp60c-src
T O Chan1, A Tanaka, J D Bjorge
1Department of Medical Biochemistry, University of Calgary Medical Sciences Centre, Alberta, Canada.
Abstract:
Chicken embryo fibroblast cells overexpressing activated mutant forms of human pp60c-src, but not those overexpressing normal human pp60c-src, exhibited high levels of type I phosphatidylinositol (PI) kinase activity associated with pp60c-src. Levels of PI kinase activity were positively correlated with src tyrosine protein kinase activity and not with absolute levels of pp60c-src. Our results suggest that a linkage exists between certain forms of pp60c-src and the PI signal transduction pathway.
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