Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Epigenetic Regulation01:37

Epigenetic Regulation

Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
Epigenetic Regulation01:46

Epigenetic Regulation

Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
Genomic Imprinting and Inheritance02:30

Genomic Imprinting and Inheritance

Diploid organisms inherit genetic material through chromosomes from both parents. Copies of the same gene are known as alleles. In most cases, both alleles are simultaneously expressed and allow various cellular processes to function optimally. If one of the alleles is missing or mutated, the expression of the other allele can compensate; however, this is not true for all genes.
The expression of some genes depends on which parent passed the gene to the offspring, through a phenomenon known as...
General Transcription Factors01:30

General Transcription Factors

Tissue-specific transcription factors contribute to diverse cellular functions in mammals. For example, the gene for beta globin, a major component of hemoglobin, is present in all cells of the body. However, it is only expressed in red blood cells because the transcription factors that can bind to the promoter sequences of the beta globin gene are only expressed in these cells. Tissue-specific transcription factors also ensure that mutations in these factors may impair only the function of...
Gene-Environment Interactions01:20

Gene-Environment Interactions

Gene expression is a dynamic process that is significantly influenced by environmental factors. This interaction underlies the complex nature of biological development and the phenotypic differences observed among individuals, even among those with identical genetic makeups. Factors such as radiation, temperature, behavior, nutrition, and stress play pivotal roles in determining how genes are expressed. The concept of the reaction range is central to understanding this interaction. It posits...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Desmoglein-2 Deficiency Drives Mitochondrial Morphological Remodeling in Cardiomyocytes.

American journal of physiology. Heart and circulatory physiology·2026
Same author

Repeated heat exposure upregulates skeletal muscle aquaporin-4 expression in male mice.

Physiological reports·2026
Same author

3D Imaging of Gene Expression Domains in the Mouse Heart.

Methods in molecular biology (Clifton, N.J.)·2026
Same author

Machine Learning in Nonischemic Cardiomyopathy: Phenotyping, Mechanism Discovery, and Clinical Applications.

Cardiology in review·2026
Same author

Machine learning models enhance detection of arrhythmogenic right ventricular cardiomyopathy.

Machine learning. Health·2026
Same author

Transcriptome-based maturation assessment revealed pro-maturation transcription factors of cardiomyocytes.

Frontiers in bioengineering and biotechnology·2026
Same journal

YAP plays a critical role in myocardial recovery from myocarditis by suppressing IFN-γ signaling pathway.

Cardiovascular research·2026
Same journal

Metabolic crisis and TRPM4 activation cause QT prolongation in TANGO2 deficiency disorder.

Cardiovascular research·2026
Same journal

Personalizing Atrial Fibrillation Therapy: Moving from Genetic Association to Mechanistic Translation.

Cardiovascular research·2026
Same journal

Placental Growth Factor Promotes Endothelial Activation and Inflammatory Remodelling in Pulmonary Hypertension.

Cardiovascular research·2026
Same journal

Endothelial-to-mesenchymal transition (EndMT) in atherosclerosis: mechanisms, models and therapies.

Cardiovascular research·2026
Same journal

The gut-heart axis in cardio-oncology.

Cardiovascular research·2026
See all related articles

Related Experiment Video

Updated: Jun 1, 2026

Epigenetic Regulation of Cardiac Differentiation of Embryonic Stem Cells and Tissues
13:03

Epigenetic Regulation of Cardiac Differentiation of Embryonic Stem Cells and Tissues

Published on: June 3, 2016

Epigenetic factors and cardiac development.

Jan Hendrick van Weerd1, Kazuko Koshiba-Takeuchi, Chulan Kwon

  • 1Cardiovascular Regeneration, Institute of Molecular and Cellular Biosciences, University of Tokyo, Tokyo, Japan.

Cardiovascular Research
|May 25, 2011
PubMed
Summary
This summary is machine-generated.

Epigenetic factors and chromatin remodelling are crucial for heart development and regeneration. Understanding these mechanisms offers new insights into preventing congenital heart defects and advancing cardiac therapies.

More Related Videos

An Efficient Transgenesis Approach for Gene Delivery in the Mouse Embryonic Heart
05:06

An Efficient Transgenesis Approach for Gene Delivery in the Mouse Embryonic Heart

Published on: May 24, 2024

Analysis of Cardiac Chamber Development During Mouse Embryogenesis Using Whole Mount Epifluorescence
06:27

Analysis of Cardiac Chamber Development During Mouse Embryogenesis Using Whole Mount Epifluorescence

Published on: April 17, 2019

Related Experiment Videos

Last Updated: Jun 1, 2026

Epigenetic Regulation of Cardiac Differentiation of Embryonic Stem Cells and Tissues
13:03

Epigenetic Regulation of Cardiac Differentiation of Embryonic Stem Cells and Tissues

Published on: June 3, 2016

An Efficient Transgenesis Approach for Gene Delivery in the Mouse Embryonic Heart
05:06

An Efficient Transgenesis Approach for Gene Delivery in the Mouse Embryonic Heart

Published on: May 24, 2024

Analysis of Cardiac Chamber Development During Mouse Embryogenesis Using Whole Mount Epifluorescence
06:27

Analysis of Cardiac Chamber Development During Mouse Embryogenesis Using Whole Mount Epifluorescence

Published on: April 17, 2019

Area of Science:

  • Developmental biology
  • Regenerative medicine
  • Cardiology

Background:

  • Congenital heart malformations are the leading cause of birth defect-related mortality.
  • Heart development is regulated by complex genetic and epigenetic transcriptional networks.
  • Recent research highlights the significant role of epigenetic factors in cardiac studies.

Purpose of the Study:

  • To review the function of chromatin remodelling factors in cardiac development.
  • To synthesize current knowledge on cardiac morphogenesis, regeneration, and direct cardiac differentiation.
  • To emphasize the recent discoveries concerning epigenetic factors in the cardiac field.

Main Methods:

  • Literature review of developmental and regenerative cardiology.
  • Analysis of genetic and epigenetic regulatory mechanisms in heart development.
  • Synthesis of data on chromatin remodelling factors' roles.

Main Results:

  • Chromatin remodelling factors play essential roles in cardiac development.
  • Epigenetic mechanisms are integral to cardiac morphogenesis and regeneration.
  • Significant advancements in understanding these factors have occurred in the last five years.

Conclusions:

  • Epigenetic factors are critical regulators of cardiac development and regeneration.
  • Further research into these mechanisms can inform strategies for congenital heart defect treatment.
  • The field of cardiac research has been significantly advanced by the study of epigenetic factors.