Papular and papulovesicular acrolocated eruptions and viral infections
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A Patrizi1, V Di Lernia, G Ricci
1Department of Dermatology, University of Bologna, Italy.
Insights
This study investigated viral links in childhood skin eruptions, finding connections between various viral infections and papular or papulovesicular acrolocated rashes. Early virologic testing is recommended for accurate diagnosis.
Area of Science:
- Pediatrics
- Virology
- Dermatology
Background:
- Papular or papulovesicular acrolocated eruptions are common in children.
- The etiology of these eruptions is often unclear.
- Viral infections are suspected but not consistently identified.
Purpose of the Study:
- To evaluate the association between viral infections and symmetric papular or papulovesicular acrolocated eruptions in children.
- To identify specific viral pathogens implicated in these dermatologic conditions.
Main Methods:
- Study included 26 children with symmetric papular/papulovesicular acrolocated eruptions.
- Investigated recent immunizations, including polio vaccine.
- Performed serologic tests for Epstein-Barr virus, adenovirus, and cytomegalovirus.
- Conducted viral cultures for adenovirus and rotavirus.
Main Results:
- Four patients had recent immunization history; two had polio vaccine virus in stool.
- Serologic evidence of Epstein-Barr virus, adenovirus, and cytomegalovirus infections found in four patients.
- Viral cultures positive for adenovirus (2 patients) and rotavirus (2 patients).
Conclusions:
- Multiple viral infections can be associated with childhood papular and papulovesicular acrolocated eruptions.
- Virologic investigations in early stages are crucial for identifying causative agents.
- Findings suggest a significant role for viral etiology in these pediatric skin conditions.
Abstract:
Twenty-six children with a symmetric papular or papulovesicular acrolocated eruption were studied to evaluate a possible link with viral infection. A history of a recent immunization was present in four patients, two of whom had a polio vaccine virus isolated from their stool samples. There was serologic evidence of a recent Epstein-Barr virus infection in one patient, adenovirus infection in another, a concurrent Epstein-Barr virus and adenovirus infection in a third, and cytomegalovirus infection in a fourth. Viral cultures were positive in two patients for adenovirus and in two others for rotavirus. Although some of the virologic findings could have been coincidental, this study confirms that multiple viral infections can be related to most papular and papulovesicular acrolocated eruptions of childhood. Virologic investigations in the earlier phases of the eruption are recommended to identify the etiologic factors of these lesions.