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Updated: Jun 1, 2026

A 3D Cartographic Description of the Cell by Cryo Soft X-ray Tomography
Published on: March 15, 2021
X-ray scattering tomography for biological applications
1Biomedical Imaging Division, VT-WFU School of Biomedical Engineering and Sciences, Virginia Polytechnic Institute and State University, Blacksburg, VA, USA. congw@vt.edu
Abstract:
The conventional attenuation contrast imaging does not yield satisfactory sensitivity and specificity for weakly absorbing media, such as biological soft tissues. The x-ray scattering offer an important contrast mechanism to reveal structural features and density fluctuation within an object. This scattering signal carries information at the molecular and supra-molecular level, and has a tremendous implication for biomedical and other applications. In this paper, we develop a scattering imaging approach to reconstruct the electron density distribution of an object and demonstrate its feasibility in the numerical simulation.
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