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Updated: May 5, 2026
10:14
An Efficient Sieving Method to Isolate Intact Glomeruli from Adult Rat Kidney
Published on: November 1, 2018
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The targeted podocyte
1Department of Pathology, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA. agnes.fogo@vanderbilt.edu
The Journal of Clinical Investigation
|May 25, 2011
Summary
Podocyte injury causes kidney disease. Manipulating the mammalian target of rapamycin (mTOR) pathway specifically in podocytes impacts proteinuria and sclerosis, revealing pathway complexity.
Area of Science:
- Nephrology
- Molecular Biology
- Cell Biology
Background:
- Podocytes are crucial for glomerular filtration and kidney structure.
- Podocyte damage leads to proteinuria and kidney scarring (sclerosis).
- Mammalian target of rapamycin (mTOR) inhibitors have shown mixed effects on kidney disease.
Purpose of the Study:
- To investigate the role of the mTOR pathway in podocyte function.
- To understand how podocyte-specific mTOR manipulation affects kidney disease progression.
Main Methods:
- Studies involved podocyte-specific manipulation of the mTOR system.
- Experimental models and/or human disease data were analyzed.
Main Results:
- Podocyte-specific mTOR pathway alterations influenced proteinuria.
- Changes in the mTOR system affected glomerular sclerosis.
- The effects of mTOR manipulation were complex and context-dependent.
Conclusions:
- The mTOR pathway's role in podocytes is intricate.
- Targeting mTOR in podocytes presents a complex therapeutic strategy for kidney disease.
- Further research is needed to fully elucidate mTOR signaling in podocytes.
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