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Two atypical cases of cutaneous gamma/delta T-cell lymphomas
A Caudron1, J D Bouaziz, M Battistella
1Department of Dermatology, AP-HP, Saint-Louis Hospital, Paris, France. acaudron02@gmail.com
Dermatology (Basel, Switzerland)
|May 25, 2011
Summary
Cutaneous γ/δ T-cell lymphoma (CGD-TCL) is a rare and aggressive skin cancer. Diagnosis can be challenging, but techniques like PCR and EBV testing aid in identifying this rare lymphoma.
Area of Science:
- Dermatology
- Oncology
- Immunology
Background:
- Cutaneous γ/δ T-cell lymphoma (CGD-TCL) is a recently classified cutaneous lymphoma.
- It is characterized by atypical lymphocytes expressing the γ/δ T-cell receptor.
- Primary CGD-TCL is rare and has an aggressive clinical course with a median survival of 15 months.
Observation:
- Two atypical cases of CGD-TCL are presented.
- The first case was initially misdiagnosed as inflammatory panniculitis due to granulomatous infiltrates.
- The second case is the first reported instance of Epstein-Barr virus (EBV)-associated CGD-TCL.
Findings:
- Diagnosis was confirmed by δ PCR revealing γ/δ T-cell clonal expansion.
- The first case showed diffuse body fat involvement on PET-CT.
- The second case presented with a rapidly fatal evolution.
Implications:
- CGD-TCL is a heterogeneous entity.
- δ PCR is crucial for diagnosing γ/δ T-cell clonal expansion.
- EBV-encoded RNA (EBER) probes can help detect EBV latent infection, aiding diagnosis and characterization of these lymphomas.
