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Updated: Jun 1, 2026
06:53
A Rat Tibial Growth Plate Injury Model to Characterize Repair Mechanisms and Evaluate Growth Plate Regeneration Strategies
Published on: July 4, 2017
[Legg-Calvé-Perthes disease]
Ola Wiig1, Svein Svenningsen, Terje Terjesen
1Ortopedisk avdeling, Oslo universitetssykehus, Norway. ola.wiig@oslo-universitetssykehus.no
Summary
Legg-Calvé-Perthes disease (LCPD) affects children, causing avascular necrosis of the femur head. Surgery is recommended for older children with extensive necrosis, while younger children benefit from symptomatic treatment.
Area of Science:
- Pediatric Orthopedics
- Avascular Necrosis Research
- Skeletal Dysplasia Studies
Background:
- Legg-Calvé-Perthes disease (LCPD) involves avascular necrosis of the femoral head.
- Epidemiology, etiology, treatment, and prognosis are key aspects of LCPD.
Purpose of the Study:
- To review the epidemiology, causes, treatment, and prognostic factors of Legg-Calvé-Perthes disease.
- To analyze a Norwegian countrywide study on LCPD management.
Main Methods:
- Non-systematic literature review.
- Analysis of clinical practice.
- Inclusion of a Norwegian nationwide study on pediatric LCPD.
Main Results:
- LCPD incidence varies globally.
- Older age at diagnosis and >50% femoral head necrosis correlate with poorer prognosis.
- Varus femoral osteotomy showed superior outcomes in older children with extensive necrosis compared to physiotherapy or orthosis.
Conclusions:
- Surgical intervention (varus femoral osteotomy) is advised for children aged six years or older with >50% femoral head necrosis.
- Symptomatic treatment is recommended for younger children or those with <50% necrosis.
- Abduction orthosis is not indicated for LCPD treatment.
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