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Assessment of the Immunomodulatory Properties of Human Mesenchymal Stem Cells (MSCs)
06:20

Assessment of the Immunomodulatory Properties of Human Mesenchymal Stem Cells (MSCs)

Published on: December 24, 2015

Immunological properties of embryonic and adult stem cells

Francesco Bifari1, Luciano Pacelli, Mauro Krampera

  • 1Francesco Bifari, Luciano Pacelli, Mauro Krampera, Stem Cell Research Laboratory, Section of Hematology, Department of Medicine, University of Verona, Pz.le Scuro 10, 37134 Verona, Italy.

World Journal of Stem Cells
|May 25, 2011
PubMed

The possibility of treating degenerative diseases by stem cell-based approaches is a promising therapeutical option. Among major concerns for the clinical application of stem cells, some derive from the possibility that stem cells may be rejected by the immune system as a consequence of histoincompatibility and that stem cells themselves may interfere with the normal functions of host immune response. Therefore, the immunogenicity and the immunomodulatory properties of stem cells must be carefully addressed. Although these properties are common features of different stem cell types, some peculiarities can be recognized and characterized for their proper clinical use.

Keywords:
Embryonic stem cellsImmune suppressionImmunogenicityMesenchymal stem cellsNeural stem cellsRegenerative medicine

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