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Disentangling Glycan-Protein Interactions: Nuclear Magnetic Resonance (NMR) to the Rescue
Published on: May 17, 2024
A rigid lanthanide binding tag for NMR structural analysis of carbohydrates
Alvaro Mallagaray1, Angeles Canales, Gema Domínguez
1Facultad de Farmacia, Dpto. Química, Universidad San Pablo CEU, Urb. Montepríncipe, ctra. Boadilla km 5, 300 Boadilla del Monte, 28668 Madrid, Spain.
Chemical Communications (Cambridge, England)
|May 25, 2011
Abstract:
The first synthesis of a carbohydrate molecule covalently bound to a rigid lanthanide binding tag is reported. This derivative has been designed as a new tool to provide long-range restraints for structural elucidation and molecular recognition studies of carbohydrates, thus extending the methodology already developed for proteins.
