The addition of mesna to hyperhydration does not decrease the incidence of hemorrhagic cystitis in patients receiving
C Murphy1, E Harden, D Stevens
1JAMES RIVER CLIN,NEWPORT NEWS,VA 23606. W VIRGINIA UNIV,HLTH SCI CTR,DEPT MED,MARY BABB CANC CTR,BONE MARROW TRANSPLANTAT PROGR,MORGANTOWN,WV 26506. UNIV LOUISVILLE,JAMES GRAHAM BROWN CANC CTR,LOUISVILLE,KY 40292.
Oncology Reports
|May 25, 2011
Summary
Adding mesna to hyperhydration did not significantly reduce hemorrhagic cystitis in patients receiving cyclophosphamide. Hyperhydration alone appears sufficient for preventing this side effect.
Area of Science:
- Oncology
- Pharmacology
- Urology
Background:
- Cyclophosphamide is a widely used chemotherapy agent.
- Hemorrhagic cystitis is a significant side effect of cyclophosphamide treatment.
- Hyperhydration is a standard preventative measure against hemorrhagic cystitis.
Purpose of the Study:
- To evaluate the added benefit of mesna in combination with hyperhydration for preventing cyclophosphamide-induced hemorrhagic cystitis.
- To compare the incidence of hemorrhagic cystitis in patients receiving hyperhydration alone versus hyperhydration plus mesna.
Main Methods:
- A retrospective analysis of 110 patients receiving hyperhydration alone and 107 patients receiving hyperhydration plus mesna.
- Patients received cyclophosphamide as part of a dose-intensive regimen.
- Incidence of macroscopic hematuria was recorded.
Main Results:
- Macroscopic hematuria occurred in 16% of patients receiving hyperhydration alone and 8% of patients receiving hyperhydration plus mesna (p=0.08).
- The addition of mesna to hyperhydration did not show a statistically significant benefit in preventing hemorrhagic cystitis.
Conclusions:
- Hyperhydration alone may be sufficient for preventing cyclophosphamide-induced hemorrhagic cystitis.
- Further research may be needed to clarify the role of mesna in specific patient populations or with different cyclophosphamide dosing strategies.
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