Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Gene Duplication and Divergence02:37

Gene Duplication and Divergence

The seminal work of Ohno in 1970 popularized the idea of gene duplication and divergence. DNA sequence comparison studies reveal that a large portion of the genes in bacteria, archaebacteria, and eukaryotes was  generated by gene duplication and divergence, indicating its critical role in evolution.
The duplicated copies of the gene are called Paralogs. Paralogs with similar sequences and functions form a gene family. Across several species, a large number of gene families are characterized.
Chromosome Duplication02:05

Chromosome Duplication

The process of chromosome duplication during cell division requires genome-wide disruption and re-assembly of chromatin. The chromatin structure must be accurately inherited, reassembled, and maintained in the daughter cells to ensure lineage propagation.
The basic unit of the chromatin is the nucleosome, consisting of DNA wrapped around octameric histone proteins and short stretches of linker DNA separating individual nucleosomes. The histone proteins within the nucleosome have their...
Cancer-Critical Genes I: Proto-oncogenes01:33

Cancer-Critical Genes I: Proto-oncogenes

Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
Cancer-Critical Genes I: Proto-oncogenes01:33

Cancer-Critical Genes I: Proto-oncogenes

Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
Centrosome Duplication02:25

Centrosome Duplication

The primary microtubule organizing center (MTOC) in animal cells is the centrosome. A centrosome has two cylindrical centrioles at its core. Each centriole consists of nine sets of three microtubules held together by proteins. The centrioles are positioned at right angles to each other and surrounded by a shapeless protein cloud called the pericentriolar matrix, or pericentriolar material (PCM).
To ensure that each daughter cell receives a centrosome after cell division, centrosome duplication...
Centrosome Duplication02:25

Centrosome Duplication

The primary microtubule organizing center (MTOC) in animal cells is the centrosome. A centrosome has two cylindrical centrioles at its core. Each centriole consists of nine sets of three microtubules held together by proteins. The centrioles are positioned at right angles to each other and surrounded by a shapeless protein cloud called the pericentriolar matrix, or pericentriolar material (PCM).
To ensure that each daughter cell receives a centrosome after cell division, centrosome duplication...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Polar lipids and proteins in milk fat globule membranes as players in spontaneous lipolysis in cow's milk.

Food chemistry·2025
Same author

Falsely reassuring impedance in a patient with deep brain stimulation: a case report.

Journal of neurology·2024
Same author

Epidemiology of breast cancer in women based on diagnosis data from oncologists and senologists in Algeria.

Cancer treatment and research communications·2020
Same author

Review of basal-plus insulin regimen options for simpler insulin intensification in people with Type 2 diabetes mellitus.

Diabetic medicine : a journal of the British Diabetic Association·2017
Same author

Drowning associated pneumonia: a descriptive cohort.

Resuscitation·2011
Same author

Intragenomic and intraspecific heterogeneity of the 16S rRNA gene in seven bacterial species from the respiratory tract of cystic fibrosis patients assessed by PCR-Temporal Temperature Gel Electrophoresis.

Pathologie-biologie·2011
Same journal

Identification of RRM2 as a key regulator of malignant epithelial cells in gastric cancer through single‑cell transcriptomics.

Oncology reports·2026
Same journal

Impact of WFDC2 on the biological functions of cervical cancer cells and the regulation of the ERK/NF‑κB signaling pathway.

Oncology reports·2026
Same journal

Schisandrin B exhibits anti‑proliferative effects by inducing ferroptosis in pancreatic cancer.

Oncology reports·2026
Same journal

Research advances on DKK1 in head and neck squamous cell carcinoma: Linking molecular mechanisms to clinical applications (Review).

Oncology reports·2026
Same journal

PI3Kδ inhibitor YY‑20394 is effective alone or in combination with Bcl‑2 inhibitor ABT199 in acute myeloid leukemia cells.

Oncology reports·2026
Same journal

A fibroblast activation protein degrader enhances cisplatin sensitivity in non‑small cell lung cancer.

Oncology reports·2026
See all related articles

Related Experiment Video

Updated: Jun 1, 2026

Robust Detection of Gene Amplification in Formalin-Fixed Paraffin-Embedded Samples by Fluorescence In Situ Hybridization
03:55

Robust Detection of Gene Amplification in Formalin-Fixed Paraffin-Embedded Samples by Fluorescence In Situ Hybridization

Published on: July 12, 2024

Oncogenesis and genome duplication maps (commentary).

D Birnbaum, M Pebusque, A Imbert

    Oncology Reports
    |May 25, 2011
    PubMed
    Summary
    This summary is machine-generated.

    This study explores how cancer gene activation relates to genome duplications. Understanding gene structure and location can identify duplications and predict cancer gene behavior.

    More Related Videos

    Genome-wide Purification of Extrachromosomal Circular DNA from Eukaryotic Cells
    14:26

    Genome-wide Purification of Extrachromosomal Circular DNA from Eukaryotic Cells

    Published on: April 4, 2016

    Related Experiment Videos

    Last Updated: Jun 1, 2026

    Robust Detection of Gene Amplification in Formalin-Fixed Paraffin-Embedded Samples by Fluorescence In Situ Hybridization
    03:55

    Robust Detection of Gene Amplification in Formalin-Fixed Paraffin-Embedded Samples by Fluorescence In Situ Hybridization

    Published on: July 12, 2024

    Genome-wide Purification of Extrachromosomal Circular DNA from Eukaryotic Cells
    14:26

    Genome-wide Purification of Extrachromosomal Circular DNA from Eukaryotic Cells

    Published on: April 4, 2016

    Area of Science:

    • Genetics
    • Cancer Biology
    • Genomics

    Background:

    • Multigene families contain numerous genes with related functions.
    • Cancer gene activation is a key process in tumorigenesis.
    • Genome duplications can alter gene dosage and function.

    Purpose of the Study:

    • To investigate the relationship between cancer gene activation and genome duplications.
    • To explore how gene structure and chromosomal location inform the identification of genome duplications.
    • To determine if genome duplication maps can predict cancer gene behavior.

    Main Methods:

    • Analysis of known cancer genes within multigene families.
    • Examination of gene structure and chromosomal mapping.
    • Correlation of gene locations with known genome duplication patterns.

    Main Results:

    • Specific examples of activated cancer genes belonging to multigene families are presented.
    • Gene structure and chromosomal location were found to be indicative of genome duplications.
    • Genome duplication maps showed potential in predicting the location and behavior of cancer genes.

    Conclusions:

    • Cancer gene activation is linked to genome duplication events.
    • Chromosomal location and gene structure are crucial for identifying genome duplications.
    • Genome duplication mapping offers a predictive tool for cancer gene research.