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Immunohistochemically demonstrable pp60(c-SRC) in human breast-cancer
Oncology Reports
|May 25, 2011
Summary
Elevated levels of pp60(c-src) tyrosine kinase were observed in many human breast cancers. While not universally linked to poor prognosis, increased pp60(c-src) may drive malignant cell proliferation.
Area of Science:
- Oncology
- Molecular Biology
- Cancer Research
Background:
- Elevated protein-tyrosine kinase activity of pp60(c-src) is linked to shorter disease-free periods in breast cancer patients.
- In colon cancer, pp60(c-src) protein levels correlate with tumor malignancy grade.
Purpose of the Study:
- To investigate the expression of pp60(c-src) in human breast cancers.
- To compare pp60(c-src) levels with prognostic histopathological factors.
Main Methods:
- Immunohistochemical demonstration of pp60(c-src) in 48 human breast cancer samples.
- Comparison of pp60(c-src) levels with tumor size, axillary metastases, and malignancy grade.
Main Results:
- A weakly positive pp60(c-src) reaction was found in normal cells and 40% of breast cancers.
- Increased pp60(c-src) levels and elevated reaction intensity were observed in 60% of breast cancers, with cytoplasmic and nuclear localization.
- No statistically significant differences in prognostic factors were found between low and high pp60(c-src) groups.
Conclusions:
- pp60(c-src) is not primarily associated with the malignant growth of all human breast cancers.
- Elevated pp60(c-src) may contribute to malignant cell proliferation in a significant subset of breast cancers.
