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Immunohistochemically demonstrable pp60(c-SRC) in human breast-cancer.

Oncology Reports

|May 25, 2011

Summary

Elevated levels of pp60(c-src) tyrosine kinase were observed in many human breast cancers. While not universally linked to poor prognosis, increased pp60(c-src) may drive malignant cell proliferation.

Area of Science:

Oncology
Molecular Biology
Cancer Research

Background:

Elevated protein-tyrosine kinase activity of pp60(c-src) is linked to shorter disease-free periods in breast cancer patients.
In colon cancer, pp60(c-src) protein levels correlate with tumor malignancy grade.

Purpose of the Study:

To investigate the expression of pp60(c-src) in human breast cancers.
To compare pp60(c-src) levels with prognostic histopathological factors.

Main Methods:

Immunohistochemical demonstration of pp60(c-src) in 48 human breast cancer samples.
Comparison of pp60(c-src) levels with tumor size, axillary metastases, and malignancy grade.

Main Results:

A weakly positive pp60(c-src) reaction was found in normal cells and 40% of breast cancers.

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Increased pp60(c-src) levels and elevated reaction intensity were observed in 60% of breast cancers, with cytoplasmic and nuclear localization.

No statistically significant differences in prognostic factors were found between low and high pp60(c-src) groups.

Conclusions:

pp60(c-src) is not primarily associated with the malignant growth of all human breast cancers.
Elevated pp60(c-src) may contribute to malignant cell proliferation in a significant subset of breast cancers.