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The value of the lysosomal protease cathepsin-d in egyptian bladder-cancer

S Eissa1, O Elahmady, A Eldin

  • 1AL-AZHAR UNIV,TUMOR MARKER ONCOL RES CTR,CAIRO,EGYPT. AL-AZHAR UNIV,DEPT UROL,CAIRO,EGYPT. AL-AZHAR UNIV,AIN SHAMS FAC MED,DEPT PATHOL,ONCOL DIAGNOST UNIT,CAIRO,EGYPT.

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Lysosomal Hydrolases

Lysosomes are the site for the degradation of macromolecules and biological polymers released during membrane trafficking events such as secretory, endocytic, autophagic, and phagocytic pathways. The membrane-enclosed area of the lysosome, called the lumen, contains hydrolytic enzymes active in an acidic environment. These acid hydrolases are functional at a pH between 4.5 and 5 and are involved in cellular processes such as cell signaling, energy metabolism, restoration of the plasma membrane,...