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Related Concept Videos

Abnormal Proliferation02:23

Abnormal Proliferation

Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the daughter...
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The small intestine exhibits a unique histological structure that significantly enhances its function in digestion and nutrient absorption. These structures include circular folds, villi, and various specialized cells that collectively facilitate the digestion of food.
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Updated: Jun 1, 2026

Yeast As a Chassis for Developing Functional Assays to Study Human P53
14:57

Yeast As a Chassis for Developing Functional Assays to Study Human P53

Published on: August 4, 2019

P53 expression in human small-intestinal tumors.

D Spandidos1, V Zoumpourlis, V Gorgoulis

  • 1UNIV CRETE,SCH MED,IRAKLION,GREECE. RES CROSS HOSP,ATHENS,GREECE. AF GEN & VA HOSP,ATHENS,GREECE.

Oncology Reports
|May 25, 2011
PubMed
Summary
This summary is machine-generated.

The tumor suppressor gene p53 was overexpressed in 46% of human small intestinal tumors studied. This finding suggests the p53 gene plays a role in the development of these tumors.

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Area of Science:

  • Oncology
  • Molecular Biology
  • Gastroenterology

Background:

  • The p53 gene is a critical tumor suppressor.
  • Its role in small intestinal tumors is not well understood.

Purpose of the Study:

  • To investigate the expression of p53 in human small intestinal tumors.
  • To determine if p53 is involved in the pathogenesis of these tumors.

Main Methods:

  • Immunohistochemical analysis was used to examine p53 expression.
  • The monoclonal antibody pAb240 was employed for p53 detection.

Main Results:

  • p53 overexpression was detected in 6 out of 13 (46%) small intestinal tumors.
  • Tumors with overexpression included lymphoma, angiosarcoma, leiomyosarcoma, adenocarcinoma, and metastatic colon adenocarcinomas.
  • This is the first report of p53 expression in small intestinal tumors.

Conclusions:

  • The p53 gene may be implicated in the development of small intestinal tumors.
  • Further research is warranted to elucidate the specific mechanisms involved.