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Quantitative Mass Spectrometric Profiling of Cancer-cell Proteomes Derived From Liquid and Solid Tumors
Published on: February 27, 2015
Difference in the distribution of low-molecular-weight peptides and amino-acids in normal and malignant-cells and
K Reichelt1, P Haakonsen, J Paulsen
1UNIV OSLO,NATL HOSP,RIKSHOSP,INST PATHOL,N-0027 OSLO,NORWAY.
Oncology Reports
|May 25, 2011
Abstract:
The amount of low molecular weight amino acids and peptides measured in the form amino acids released by hydrolysis was found to be very low in malignant tissues and cell lines compared to normal tissues and cell lines. The ratios of acid soluble proteins to these low molecular weight compounds were statistically different in normal and malignant cells. The difference may reflect faster growth, greater membrane permeability or other aspects of the malignant process itself.
