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Medroxyprogesterone acetate (mpa) increases pai-1 secretion from huvec and elevates the plasma-levels of pai-I

K Serizawa1, T Urano, Y Kojima

  • 1HAMAMATSU UNIV,SCH MED,DEPT PHYSIOL,HAMAMATSU,SHIZUOKA 43131,JAPAN. HAMAMATSU UNIV,SCH MED,DEPT MED,HAMAMATSU,SHIZUOKA 43131,JAPAN. MARUMO HOSP,NAGOYA,AICHI,JAPAN.

Oncology Reports
|May 25, 2011
PubMed

Insights

Medroxyprogesterone acetate (MPA) significantly increased active plasminogen activator inhibitor-1 (PAI-1) levels in patients. In vitro, MPA decreased PAI-1 in endothelial cells, suggesting a complex role in fibrinolysis.

Area of Science:

  • Endocrinology
  • Hematology
  • Pharmacology

Background:

  • Medroxyprogesterone acetate (MPA) and tamoxifen are commonly used in hormone therapies.
  • Tissue plasminogen activator (t-PA) and plasminogen activator inhibitor-1 (PAI-1) are key regulators of fibrinolysis.
  • Understanding the impact of these drugs on hemostatic factors is crucial for patient management.

Purpose of the Study:

  • To investigate the effects of MPA and tamoxifen on plasma levels of t-PA and PAI-1.
  • To examine the in vitro effects of MPA on PAI-1 and t-PA in endothelial cells.

Main Methods:

  • Plasma samples from patients receiving MPA or tamoxifen were analyzed for t-PA and PAI-1 levels.
  • In vitro studies involved treating human umbilical vein endothelial cells (HUVEC) with MPA.
  • Assays were performed to measure active free PAI-1 and t-PA antigen levels.

Main Results:

  • Patients treated with MPA exhibited significantly higher active free PAI-1 levels compared to tamoxifen or post-adjuvant therapy groups.
  • No significant differences in t-PA antigen levels were observed among the treatment groups.
  • In vitro, MPA treatment led to a significant decrease in PAI-1 levels and a trend towards decreased t-PA levels in HUVECs.

Conclusions:

  • MPA administration is associated with elevated active free PAI-1 levels in patients.
  • MPA may directly influence endothelial cell PAI-1 production.
  • These findings suggest MPA could impact fibrinolytic balance, warranting further investigation.

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