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What is intrinsic atopic dermatitis?
Anne-Marie Roguedas-Contios1, Laurent Misery
1University of Brest, France. anne-marie.roguedas-contios@chu-brest.fr
Clinical Reviews in Allergy & Immunology
|May 25, 2011
Summary
Distinguishing between intrinsic and extrinsic atopic dermatitis is beneficial due to differing pathophysiology. Further research is needed to clarify definitions and confirm the existence of these two distinct forms of eczema.
Area of Science:
- Dermatology
- Immunology
- Genetics
Background:
- Atopic dermatitis (AD) classification often involves distinguishing between extrinsic and intrinsic forms.
- The distinction between these forms remains a subject of debate among researchers.
- Existing definitions for intrinsic and extrinsic AD lack concrete clarification.
Purpose of the Study:
- To review the controversy surrounding the classification of atopic dermatitis.
- To present various definitions for intrinsic and extrinsic atopic dermatitis.
- To argue for the utility of separating intrinsic and extrinsic AD based on potential pathophysiological differences.
Main Methods:
- Comprehensive literature review of studies discussing atopic dermatitis classification.
- Analysis of existing definitions and proposed distinctions between AD forms.
- Synthesis of evidence supporting or refuting the separation of intrinsic and extrinsic AD.
Main Results:
- The review highlights ongoing debate and varied definitions for intrinsic and extrinsic atopic dermatitis.
- Evidence suggests potential differences in pathophysiology between the two proposed forms.
- Genetic variations may support the existence of distinct intrinsic and extrinsic types of AD.
Conclusions:
- Separating intrinsic and extrinsic atopic dermatitis is proposed as a useful clinical and research approach.
- Clearer definitions and concrete distinctions are required for these classifications.
- Further investigation into genetic and pathophysiological differences is warranted to validate the existence of two distinct forms of atopic dermatitis.
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