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Negative correlation between aqueous vascular endothelial growth factor levels and axial length
Osamu Sawada1, Taichiro Miyake2, Masashi Kakinoki2
1Department of Ophthalmology, Shiga University of Medical Science, Seta Tsukinowacho, Otsu, Shiga, 520-2192, Japan. osawada@belle.shiga-med.ac.jp.
Japanese Journal of Ophthalmology
|May 25, 2011
Summary
Vascular endothelial growth factor (VEGF) levels in aqueous humor correlate negatively with eye axial length in cataract patients. Lower VEGF concentrations are associated with longer eyes.
Area of Science:
- Ophthalmology
- Ocular Biology
- Biochemistry
Background:
- Vascular endothelial growth factor (VEGF) plays a critical role in ocular angiogenesis and vascular permeability.
- Understanding VEGF's role in ocular structures is crucial for diagnosing and managing various eye conditions.
Purpose of the Study:
- To investigate the association between aqueous humor vascular endothelial growth factor (VEGF) concentrations and axial length.
- To determine if VEGF levels correlate with the physical dimensions of the eye.
Main Methods:
- Aqueous humor samples were collected from 60 cataract patients without other ocular diseases or diabetes.
- Vascular endothelial growth factor (VEGF) concentrations were quantified using enzyme-linked immunosorbent assay (ELISA).
- Axial length measurements were obtained for all participants.
Main Results:
- A significant negative correlation was observed between aqueous humor VEGF concentrations and axial length (ρ = -0.373; P = 0.003).
- VEGF levels ranged from 25 to 241 pg/ml (mean ± SD, 116.6 ± 46.7 pg/ml).
- Axial lengths varied from 20.98 to 31.95 mm (mean ± SD, 24.09 ± 2.06 mm).
Conclusions:
- Aqueous humor vascular endothelial growth factor (VEGF) concentration is inversely related to axial length.
- This finding suggests a potential link between VEGF and eye growth regulation.
