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Related Concept Videos

Drug Discovery: Overview01:26

Drug Discovery: Overview

Drug discovery is a multifaceted process involving extensive screening, testing, and optimization of lead compounds to identify potential new drugs for therapeutic use. It combines several approaches, including screening large numbers of natural products, chemical modification of known active molecules, identification of new drug targets, and rational design based on biological mechanisms and drug-receptor structure. These approaches are carried out in both academic research laboratories and...
Prescription, Nonprescription and Orphan Drugs01:02

Prescription, Nonprescription and Orphan Drugs

Prescription drugs require a prescription from a medical practitioner and can only be obtained from a pharmacy. They have many applications, including treating pain, anxiety, and hypertension.
The misuse and addiction to prescription drugs is a growing problem that can affect people of all age groups, specifically teenagers. This can happen when prescription medications are used in ways not intended by the prescriber, such as taking someone else's prescription or using medication for...
Prodrugs01:30

Prodrugs

Prodrugs are a class of pharmaceutical compounds that undergo a biotransformation process within the body to be converted into a pharmacologically active drug. Prodrugs are designed to improve the therapeutic properties of the parent drug, such as enhancing bioavailability, increasing stability, or reducing toxicity. The concept of prodrugs revolves around modifying the chemical structure of the original drug to make it more effective or convenient for administration.
Prodrugs help overcome...
Structure-Activity Relationships and Drug Design01:28

Structure-Activity Relationships and Drug Design

Drug design is a dynamic field that involves discovering and developing new medications based on specific biological targets. This process heavily relies on structure-activity relationships (SAR) and quantitative structure-activity relationships (QSAR) to guide the design and optimization of efficient drugs.
SAR studies the intricate relationship between a drug's chemical structure and biological activity. It focuses on understanding how modifications to a drug's structure can influence its...
Drug Regulation01:25

Drug Regulation

Drug regulation encompasses the management of drug usage by evaluating its safety and efficacy through assessments conducted by regulatory authorities. Regrettably, the history of drug regulation is marred by several catastrophic events. One such incident is the Elixir Sulfanilamide tragedy, in which the toxic compound diethyl glycol was included in a sweet-tasting medication, leading to numerous fatalities. This event prompted the enactment of the Food, Drug, and Cosmetic Act in 1938. Under...
Pharmacogenomics: Identification of New Drug Targets01:29

Pharmacogenomics: Identification of New Drug Targets

Advances in genomics have profoundly influenced drug discovery by increasing both the speed and accuracy of pharmaceutical development. Pharmacogenomics, which examines how genetic variation influences drug response, facilitates the identification of novel therapeutic targets and enables patient stratification for personalized treatment. These strategies contribute to improved drug efficacy, minimized adverse effects, and more efficient clinical trial design.Mapping genetic differences...

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Related Experiment Video

Updated: Jun 1, 2026

Drug Repurposing Hypothesis Generation Using the "RE:fine Drugs" System
05:10

Drug Repurposing Hypothesis Generation Using the "RE:fine Drugs" System

Published on: December 11, 2016

Finding promiscuous old drugs for new uses.

Sean Ekins1, Antony J Williams

  • 1Collaborations in Chemistry, 601 Runnymede Avenue, Jenkintown, Pennsylvania 19046, USA. ekinssean@yahoo.com

Pharmaceutical Research
|May 25, 2011
PubMed
Summary

Repurposing FDA-approved drugs for new diseases is promising. Researchers found 13 drugs active against multiple diseases, with 109 molecules identified for potential reuse, aiding drug discovery.

Area of Science:

  • Drug discovery and development
  • Pharmacology
  • Biotechnology

Background:

  • Drug repurposing leverages existing drugs for new therapeutic indications.
  • Screening FDA-approved drug libraries offers a faster route to novel bioactivities.
  • Understanding drug promiscuity is key to efficient drug repositioning.

Purpose of the Study:

  • To systematically analyze recent studies on screening FDA-approved drugs for new bioactivities.
  • To identify drugs with multi-disease activity and characterize identified molecules.
  • To create accessible databases for drug repurposing research.

Main Methods:

  • Literature review of 34 studies published in the last six years.
  • Analysis of in vitro screening data for FDA-approved drug libraries.

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High-throughput Identification of Synergistic Drug Combinations by the Overlap2 Method
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High-throughput Identification of Synergistic Drug Combinations by the Overlap2 Method

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High-throughput and Comprehensive Drug Surveillance Using Multisegment Injection-Capillary Electrophoresis-Mass Spectrometry
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High-throughput and Comprehensive Drug Surveillance Using Multisegment Injection-Capillary Electrophoresis-Mass Spectrometry

Published on: April 23, 2019

Related Experiment Videos

Last Updated: Jun 1, 2026

Drug Repurposing Hypothesis Generation Using the "RE:fine Drugs" System
05:10

Drug Repurposing Hypothesis Generation Using the "RE:fine Drugs" System

Published on: December 11, 2016

High-throughput Identification of Synergistic Drug Combinations by the Overlap2 Method
07:51

High-throughput Identification of Synergistic Drug Combinations by the Overlap2 Method

Published on: May 21, 2018

High-throughput and Comprehensive Drug Surveillance Using Multisegment Injection-Capillary Electrophoresis-Mass Spectrometry
10:17

High-throughput and Comprehensive Drug Surveillance Using Multisegment Injection-Capillary Electrophoresis-Mass Spectrometry

Published on: April 23, 2019

  • Comparative analysis of identified molecules' physicochemical properties (hydrophobicity, molecular weight, AlogP).

    • Main Results:

    • 34 studies identified novel bioactivities for existing drugs.
    • 13 drugs demonstrated activity against multiple diseases, indicating promiscuity.
    • 109 molecules were identified via in vitro screening, exhibiting higher hydrophobicity and molecular weight compared to approved orphan drugs.

    Conclusions:

    • Existing FDA-approved drugs possess significant potential for repurposing across various diseases.
    • Identified molecules possess distinct physicochemical properties that may influence their efficacy in new indications.
    • Publicly accessible databases facilitate further research and development in drug repurposing.