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Related Experiment Video

Updated: Jun 1, 2026

Non-invasive Imaging and Analysis of Cerebral Ischemia in Living Rats Using Positron Emission Tomography with 18F-FDG
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Establishing a rodent stroke perfusion computed tomography model.

Damian D McLeod1, Mark W Parsons, Christopher R Levi

  • 1School of Biomedical Sciences & Pharmacy and the Centre for Brain & Mental Health Research, University of Newcastle, Callaghan, NSW, Australia.

International Journal of Stroke : Official Journal of the International Stroke Society
|May 26, 2011
PubMed
Summary
This summary is machine-generated.

This study validates brain computed tomography perfusion imaging thresholds in a rodent stroke model. The developed model allows for future studies to optimize imaging for identifying salvageable brain tissue.

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Area of Science:

  • Neurology
  • Medical Imaging
  • Radiology

Background:

  • Acute stroke management relies on accurately identifying salvageable brain tissue (penumbra) and irreversibly damaged tissue (infarct core).
  • Perfusion computed tomography (perfusion CT) shows promise for guiding acute stroke therapy, but requires validated thresholds for infarct core and penumbra.
  • Current perfusion CT thresholds need further validation in preclinical models to ensure clinical reliability.

Purpose of the Study:

  • To validate infarct core and penumbra perfusion CT thresholds in a rodent stroke model.
  • To develop and optimize perfusion CT imaging protocols for stroke research.
  • To correlate perfusion CT findings with final histological assessment of infarction.

Main Methods:

  • Middle cerebral artery occlusion was used to induce stroke in male Wistar rats (n=17).
  • Serial perfusion CT scans were acquired pre- and post-stroke, with contrast injection and scanning parameters optimized.
  • Histological analysis of infarction was performed 24 hours post-stroke.

Main Results:

  • High-quality cerebral blood flow (CBF) and cerebral blood volume (CBV) maps were generated.
  • Significantly lower CBF was observed in the infarct core compared to the contralateral hemisphere from 1 hour post-stroke onwards.
  • Significantly lower CBV was observed in the infarct core at 1 and 1.5 hours post-stroke.

Conclusions:

  • This study demonstrates the feasibility of using perfusion CT in a common rodent stroke model.
  • The developed model provides a platform for definitive studies to determine optimal perfusion CT thresholds.
  • This research will enhance the reliability of perfusion CT for assessing infarct core and penumbra in stroke.