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Related Concept Videos

Kidney Structure01:45

Kidney Structure

The kidneys are two large bean-shaped organs located in the upper abdomen. They filter the blood several times a day to remove toxins and rebalance water and electrolytes of the circulatory system via the renal veins. The kidneys receive blood directly from the heart via the renal arteries. These arteries enter the kidney at the hilum, the concave surface of the bean, where they branch and divide into smaller vessels and capillaries.

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Related Experiment Video

Updated: Jun 1, 2026

Assessment of Kidney Function in Mouse Models of Glomerular Disease
09:16

Assessment of Kidney Function in Mouse Models of Glomerular Disease

Published on: June 30, 2018

Mouse models to study kidney development, function and disease.

Joseph P Ly1, Tuncer Onay, Susan E Quaggin

  • 1The Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Department of Medicine, University Health Network, University of Toronto, Toronto, Ontario, Canada.

Current Opinion in Nephrology and Hypertension
|May 26, 2011
PubMed
Summary
This summary is machine-generated.

Newer technologies and extensive resources enhance the mouse

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Last Updated: Jun 1, 2026

Assessment of Kidney Function in Mouse Models of Glomerular Disease
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Published on: June 30, 2018

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Published on: February 4, 2015

Area of Science:

  • Renal biology
  • Genomics
  • Molecular biology

Background:

  • Mice are the primary model organism for studying kidney gene function.
  • Conventional gene targeting and spontaneous mutations have historically advanced kidney research.

Discussion:

  • Advanced renal-specific gene-targeting tools and RNA technologies enable precise in vivo gene function manipulation.
  • International consortia are systematically targeting genes within the mouse genome.
  • Gene trap and N-ethyl-N-nitrosourea resources improve genetic manipulation efficiency.

Key Insights:

  • Modern genetic manipulation techniques offer greater precision in laboratory research.
  • The development of comprehensive mouse tool resources facilitates efficient genetic studies.

Outlook:

  • The mouse will continue to be a crucial model organism for renal function studies.
  • Ongoing technological advancements and resource availability ensure the mouse's central role in kidney research.