Herpes simplex virus activates expression of a cellular gene by specific binding to the cell surface

The herpes simplex virus (HSV) type 1 mutant ts1204 attaches to the cell surface at 38.5 degrees but fails to penetrate the plasma membrane. A striking feature of human fetal lung cells infected with ts1204 at 38.5 degrees was the presence of enhanced amounts of a 56,000 molecular weight host protein, p56. Studies with protein and RNA synthesis inhibitors suggested that binding of the mutant virus to cells activated expression of the cellular gene encoding p56 and not an intermediary protein. Evidence presented in this paper supports the idea that p56 is induced by a specific interaction between ts1204 virions and the cell surface.