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Interleukin-18 promoter polymorphism and asthma risk: a meta-analysis
Ying Ma1, Bo Zhang, Ren-Kuan Tang
1Department of Neurology, Affiliated Hospital of North Sichuan Medical College, Nanchong 637000, People's Republic of China.
Molecular Biology Reports
|May 26, 2011
Summary
Interleukin-18 (IL-18) gene promoter polymorphisms were analyzed for asthma risk. The -607C/A polymorphism showed an association with increased asthma risk, while -137G/C did not.
Area of Science:
- Genetics
- Immunology
- Respiratory Medicine
Background:
- Interleukin-18 (IL-18) is implicated in asthma etiology and progression.
- Previous studies on IL-18 gene promoter polymorphisms (-607C/A and -137G/C) and asthma risk yielded controversial results.
Purpose of the Study:
- To clarify the association between IL-18 gene promoter polymorphisms (-607C/A and -137G/C) and asthma risk.
- To provide a more precise estimation of the effect of these polymorphisms on asthma susceptibility through a meta-analysis.
Main Methods:
- A meta-analysis was conducted on published literature up to October 2010.
- Included 5 studies for -607C/A (1411 cases, 1525 controls) and 5 studies for -137G/C (1883 cases, 6645 controls).
- Fixed- and random-effects models were used to estimate odds ratios (ORs) and 95% confidence intervals (CIs); heterogeneity and publication bias were assessed.
Main Results:
- The IL-18 -607C/A polymorphism was associated with an increased asthma risk in a recessive model (OR = 1.278; 95% CI, 1.073-1.522).
- No significant association was found between the IL-18 -137G/C polymorphism and asthma risk across different models.
- No evidence of publication bias was detected for either polymorphism.
Conclusions:
- The IL-18 -607C/A polymorphism in the promoter region is associated with an increased risk of asthma.
- The IL-18 -137G/C polymorphism does not appear to be significantly associated with asthma risk.
- This meta-analysis provides stronger evidence for the role of specific IL-18 genetic variations in asthma susceptibility.
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