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Published on: March 8, 2012
Association of interleukin-6 in women with persistence of DNA-HPV: a nested case-control study
Maria Inês Rosa1, Matheus Villas Moraes, Francieli Vuolo
1Laboratory of Epidemiology and National Institute for Translational Medicine, Postgraduate Program in Health Sciences, University of the Extreme-South Catarinense, Criciuma, Brazil. mir@unesc.net
Objective:
To identify the role of Interleukin-6, IL-10 and their epidemiological association in women with persistence of DNA-HPV.
Design And Methods:
A nested case-control study within a longitudinal cohort study. Cervical specimens and blood samples were collected at enrolment from asymptomatic women who looked for a service of public health in a district of Porto Alegre, Brazil. A logistic regression analysis was performed with 95% confidence intervals. The outcome was the persistence of DNA-HPV infection.
Results:
The analysis showed that the age of the first intercourse below 20 years old (OR = 19.65, IC 95% 2.43-68.85), four or more sexual partners during lifetime (OR = 5.67, IC 95% 1.28-24.99), women with a previous altered Pap smear (OR = 10.17, IC 95% 1.80-57.33), marital status (OR = 12.94, IC 95% 2.43-68.85) and IL6 ≤ 3.106 pg/ml were associated with persistence of HPV infection. IL-10 were not associated with the HPV persistence.
Conclusion:
The present study suggests that IL-6 levels may be a marker of HPV DNA persistence, although further investigation is necessary.
