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Changes in liver enzymes and bilirubin after coronary artery bypass grafting using acute normovolemic hemodilution

S H Akhlagh1, M T M Vaziri, M H Nemati

  • 1Department of Anesthesiology, Nemazee Hospital, Shiraz University of Medical Sciences, Shiraz, Iran.

Acta Anaesthesiologica Belgica
|May 27, 2011
PubMed

Insights

Autologous blood transfusions following coronary artery bypass grafting (CABG) surgery significantly reduce postoperative jaundice compared to homologous transfusions. This study highlights potential benefits for liver health in CABG patients receiving autologous blood.

Area of Science:

  • Cardiology
  • Transfusion Medicine
  • Hepatology

Background:

  • Coronary artery bypass grafting (CABG) surgery often involves blood transfusions.
  • Postoperative jaundice and transient liver damage are potential complications.
  • Autologous and homologous blood transfusions are common practices in CABG.

Purpose of the Study:

  • To compare postoperative early jaundice and transient liver damage.
  • To evaluate outcomes in patients receiving autologous versus homologous blood transfusion during CABG.
  • To assess liver function markers post-CABG in relation to transfusion type.

Main Methods:

  • Randomized clinical trial with 40 patients undergoing CABG.
  • Patients allocated to Acute Normovolemic Hemodilution (ANH) group (autologous) or control group (homologous).
  • Comparison of bilirubin, ALT, AST, and ALP levels within the first 24 hours post-surgery.

Main Results:

  • Significant differences in total and direct bilirubin levels between groups (p<0.00001).
  • Patients receiving autologous blood (ANH group) showed significantly lower bilirubin levels.
  • No significant changes or differences in ALT, AST, and ALP levels were observed between groups.

Conclusions:

  • Autologous blood transfusion in CABG patients is associated with significantly lower postoperative bilirubin levels.
  • Autologous blood may mitigate early jaundice post-CABG compared to homologous transfusion.
  • Larger studies are needed to confirm these findings and their clinical implications.

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