Related Experiment Video

Updated: Feb 10, 2026

Sequencing Small Non-coding RNA from Formalin-fixed Tissues and Serum-derived Exosomes from Castration-resistant Prostate Cancer Patients
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Sequencing Small Non-coding RNA from Formalin-fixed Tissues and Serum-derived Exosomes from Castration-resistant Prostate Cancer Patients

Published on: November 18, 2019

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New therapeutic strategies for castration-resistant prostate cancer

Tomoaki Tanaka1, Tatsuya Nakatani

  • 1Department of Urology, Osaka City University Graduate School of Medicine, Osaka 545-8585, Japan. tomoaki826@msic.med.osaka-cu.ac.jp

Recent Patents on Anti-Cancer Drug Discovery
|May 27, 2011
PubMed

Insights

Newer treatments for metastatic castration-resistant prostate cancer (CRPC) show promise. Novel agents and multifaceted approaches, including chemotherapy and immunotherapy, are improving survival outcomes for CRPC patients.

Area of Science:

  • Oncology
  • Pharmacology

Background:

  • Metastatic castration-resistant prostate cancer (CRPC) has limited treatment options, with docetaxel offering only a modest survival benefit.
  • Research is exploring novel drug classes targeting various pathways like hormone action, bone metabolism, angiogenesis, apoptosis, and immune response to improve CRPC outcomes.

Purpose of the Study:

  • To review the latest evidence on novel agents and patented compounds for treating CRPC.
  • To discuss multifaceted therapeutic strategies combining novel agents, chemotherapy, and immunotherapy for advanced prostate cancer.

Main Methods:

  • Literature review of recent clinical trials and patented molecules.
  • Analysis of therapeutic strategies for castration-resistant prostate cancer.

Main Results:

  • Cabazitaxel and sipuleucel-T have demonstrated significant improvements in overall survival in CRPC.
  • Several patented molecules (e.g., hyaluronidase, caveolin, Bag1-L, N-cadherin, AR splicing variants, PCGEM-1) show potential for CRPC treatment.

Conclusions:

  • Effective CRPC treatment requires multifaceted approaches, including novel targeted agents, chemotherapy, and immunotherapy.
  • Emerging patented molecules offer promising therapeutic options for the future management of CRPC.

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