Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Difference from Background: Limit of Detection

Difference from Background: Limit of Detection

The limit of detection (LOD) is the smallest amount of analyte that can be distinguished from the background noise. The LOD value corresponds to the concentration at which the analyte signal is three times larger than the standard deviation of the blank signal. Below this value, the analyte signal cannot be differentiated from the background noise. It is calculated by dividing the calibration slope by 3 times the standard deviation of the blank signals.
The LOD indicates the presence or absence...

Derivatives of Inverse Trigonometric Functions

Derivatives of Inverse Trigonometric Functions

A ship tracking an approaching aircraft relies on geometric measurements to find out the aircraft’s position relative to the observer. By measuring the slant distance to the aircraft and the angle of elevation, the horizontal and vertical components of the distance can be obtained using trigonometric relationships. This geometric approach provides a basis for analyzing how the observed angle changes as the aircraft moves closer to the ship.To examine the mathematical behavior of the angle of...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Redefining Spasticity: The Spasticity X Working Group Consensus Statement.

American journal of physical medicine & rehabilitation·2026

Same author

Response to letter to the editor "Comment on: Clinical safety of ultra-high-dose methylcobalamin in patients with amyotrophic lateral sclerosis: Open-label extension of a phase 2/3 randomized controlled study".

Journal of the neurological sciences·2026

Same author

Addendum to the 2023 clinical practice guidelines for amyotrophic lateral sclerosis in Japan: approval and integration of novel disease-modifying therapies.

Rinsho shinkeigaku = Clinical neurology·2026

Same author

Clinical safety of ultra-high-dose methylcobalamin in patients with amyotrophic lateral sclerosis: Open-label extension of a phase 2/3 randomized controlled study.

Journal of the neurological sciences·2025

Same author

A genome-wide association study identifies the GPM6A locus associated with age at onset in ALS.

Communications biology·2025

Same author

Evaluation of the diagnostic performance of brachial plexus ultrasound in amyotrophic lateral sclerosis.

Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology·2025

Search research articles

Related Experiment Video

Updated: Jun 1, 2026

Open-Source Real-Time Closed-Loop Electrical Threshold Tracking for Translational Pain Research

Open-Source Real-Time Closed-Loop Electrical Threshold Tracking for Translational Pain Research

Published on: April 21, 2023

[Threshold tracking for beginners].

Yoshimitsu Shimatani¹, Hiroyuki Nodera, Ryuji Kaji

¹Department of Neurology, Tokushima University Hospital, Tokushima, Japan.

Brain and Nerve = Shinkei Kenkyu No Shinpo

|May 27, 2011

Summary

Nerve excitability testing, using threshold tracking, offers insights into nerve function and diseases like ALS. Advancements like the QTRAC program simplify these essential physiological assessments.

Area of Science:

Neurophysiology
Biophysics

Context:

Nerve excitability testing, a long-standing field, has faced technical challenges hindering its widespread application.
Pioneering work by Bergmans introduced threshold current measurement for axonal excitability studies.
The development of the semiautomatic QTRAC program by Bostock significantly streamlined nerve excitability testing.

Purpose:

To provide a comprehensive review of axonal ion channel function and investigational methodologies.
To explain the basic physiological principles required for understanding threshold tracking.
To highlight the clinical relevance of nerve excitability testing in neurological disorders.

Summary:

Nerve excitability testing, particularly threshold tracking, assesses physiological conditions, ion channels, and energy-dependent pumps.

More Related Videos

Image-based Lagrangian Particle Tracking in Bed-load Experiments

Image-based Lagrangian Particle Tracking in Bed-load Experiments

Published on: July 20, 2017

Estimating Vestibular Perceptual Thresholds Using a Six-Degree-Of-Freedom Motion Platform

Estimating Vestibular Perceptual Thresholds Using a Six-Degree-Of-Freedom Motion Platform

Published on: August 4, 2022

Related Experiment Videos

Last Updated: Jun 1, 2026

Open-Source Real-Time Closed-Loop Electrical Threshold Tracking for Translational Pain Research

Open-Source Real-Time Closed-Loop Electrical Threshold Tracking for Translational Pain Research

Published on: April 21, 2023

Image-based Lagrangian Particle Tracking in Bed-load Experiments

Image-based Lagrangian Particle Tracking in Bed-load Experiments

Published on: July 20, 2017

Estimating Vestibular Perceptual Thresholds Using a Six-Degree-Of-Freedom Motion Platform

Estimating Vestibular Perceptual Thresholds Using a Six-Degree-Of-Freedom Motion Platform

Published on: August 4, 2022

The QTRAC program enables efficient nerve excitability tests, completing them within 15 minutes.

This method provides valuable data for both normal controls and patients with conditions such as amyotrophic lateral sclerosis (ALS) and multifocal motor neuropathy (MMN).

Impact:

Facilitates a deeper understanding of nerve physiology and the role of ion channels.
Improves the diagnostic and monitoring capabilities for neurological diseases.
Enhances the practical application of nerve excitability testing in clinical neurophysiology.