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Anaplastic meningioma with extremely rapid recurrence
Yosuke Kawahara1, Mitsutoshi Nakada, Yutaka Hayashi
1Department of Neurosurgery, Graduate School of Medical Science, Kanazawa University, Ishikawa.
Neurologia Medico-Chirurgica
|May 27, 2011
Summary
Anaplastic meningioma, a rare aggressive brain tumor, can recur rapidly. High MIB-1 index indicates fast growth, necessitating prompt, multimodal treatment for brain tumor patients.
Area of Science:
- Neuro-oncology
- Neurosurgery
- Pathology
Background:
- Meningiomas are typically benign tumors arising from the meninges.
- Anaplastic meningioma (World Health Organization grade III) represents a rare, aggressive subtype.
- Early detection and understanding of aggressive tumor behavior are critical for patient outcomes.
Observation:
- A 62-year-old woman presented with memory loss due to anaplastic meningioma in the temporal lobe.
- Urgent surgery was performed for uncal herniation caused by the tumor.
- Histology revealed anaplastic meningioma with a very high MIB-1 labeling index (70%).
Findings:
- The patient experienced rapid local recurrence and dissemination within 43 days.
- The high MIB-1 index correlated with a short tumor doubling time of 8.2 days.
- Multimodal treatment including whole-brain irradiation and stereotactic radiosurgery halted tumor progression.
Implications:
- This case highlights the potential for aggressive behavior even in meningiomas.
- A high MIB-1 labeling index is a significant indicator of rapid tumor growth and recurrence risk.
- Aggressive meningiomas require consideration of multimodal treatment strategies beyond initial surgical resection.
