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Related Concept Videos

Stem Cell Therapy for Tissue Regeneration01:21

Stem Cell Therapy for Tissue Regeneration

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Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell...
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Kidney Structure01:45

Kidney Structure

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The kidneys are two large bean-shaped organs located in the upper abdomen. They filter the blood several times a day to remove toxins and rebalance water and electrolytes of the circulatory system via the renal veins. The kidneys receive blood directly from the heart via the renal arteries. These arteries enter the kidney at the hilum, the concave surface of the bean, where they branch and divide into smaller vessels and capillaries.
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Adult Stem Cells01:33

Adult Stem Cells

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Stem cells are undifferentiated cells that divide and produce more stem cells or progenitor cells that differentiate into mature, specialized cell types. All the cells in the body are generated from stem cells in the early embryo, but small populations of stem cells are also present in many adult tissues including the bone marrow, brain, skin, and gut. These adult stem cells typically produce the various cell types found in that tissue—to replace cells that are damaged or to continuously...
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Embryonic Stem Cells00:58

Embryonic Stem Cells

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Embryonic stem (ES) cells are undifferentiated pluripotent cells, meaning they can produce any cell type in the body. This gives them tremendous potential in science and medicine since they can generate specific cell types for use in research or to replace body cells lost due to damage or disease.
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Embryonic Stem Cells00:57

Embryonic Stem Cells

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Embryonic stem (ES) cells were first discovered in mice in 1981 by Martin Evans. In 1998, James Thomson identified a method to isolate embryonic stem cells from humans. Human embryonic stem cells (hESCs) are obtained from 3-5 day old embryos that remain unused after an in vitro fertilization procedure.
ES cells are grown in a culture medium where they can divide indefinitely, creating ES cell lines. Under certain conditions, ES cells can differentiate, either spontaneously into a variety of...
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Induced Pluripotent Stem Cells01:13

Induced Pluripotent Stem Cells

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Stem cells are undifferentiated cells that divide and produce different types of cells. Ordinarily, cells that have differentiated into a specific cell type are post-mitotic—that is, they no longer divide. However, scientists have found a way to reprogram these mature cells so that they “de-differentiate” and return to an unspecialized, proliferative state. These cells are also pluripotent like embryonic stem cells—able to produce all cell types—and are therefore...
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Related Experiment Video

Updated: Feb 10, 2026

Author Spotlight: Enhanced Isolation and Characterization of Vascular Wall Resident Murine CD34+ Stem Cells Using Magnetic Bead Screening-Coupled Flow Cytometry
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Author Spotlight: Enhanced Isolation and Characterization of Vascular Wall Resident Murine CD34+ Stem Cells Using Magnetic Bead Screening-Coupled Flow Cytometry

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Kidney regeneration and resident stem cells.

Scott Reule1, Sandeep Gupta

  • 1Department of Medicine, Division of Renal Diseases and Hypertension and Stem Cell Institute, University of Minnesota; Minneapolis, USA.

Organogenesis
|May 27, 2011
PubMed
Summary

Kidney injury is common, but current treatments don't aid regeneration. This review explores adult kidney stem cells and their potential role in developing novel regenerative therapies for kidney repair.

Area of Science:

  • Nephrology
  • Stem Cell Biology
  • Regenerative Medicine

Background:

  • The kidney's complex functions make it vulnerable to injury.
  • Existing therapies are insufficient for promoting kidney regeneration.
  • There is a growing need for innovative approaches to kidney repair.

Purpose of the Study:

  • To review the current understanding of stem cells within the adult mammalian kidney.
  • To discuss the potential of these stem cells in kidney regeneration.
  • To summarize evidence supporting stem cell-based kidney regeneration.

Main Methods:

  • Literature review of recent advancements in kidney stem cell research.
  • Analysis of studies investigating the role of adult kidney stem cells.
  • Synthesis of evidence for stem cell therapy in kidney regeneration.

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Isolation of Mouse Kidney-Resident CD8+ T cells for Flow Cytometry Analysis
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Related Experiment Videos

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Main Results:

  • Significant progress has been made in identifying and characterizing kidney stem cells.
  • Evidence suggests that adult kidney stem cells possess regenerative potential.
  • Stem cell therapy is a promising avenue for future kidney repair strategies.

Conclusions:

  • Adult mammalian kidneys harbor stem cells capable of regeneration.
  • Further research into kidney stem cells could lead to effective regenerative therapies.
  • Stem cell-based approaches offer hope for treating kidney diseases.