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Tumor Immunotherapy01:27

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
Cancer Vaccines01:30

Cancer Vaccines

Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
Cytotoxic T Cells-mediated Immune Response01:27

Cytotoxic T Cells-mediated Immune Response

Cytotoxic T cells are a vital component of the immune system. They have the remarkable ability to identify and target antigens on infected or abnormal cells. These antigens often originate from intracellular pathogens such as viruses or abnormal proteins cancer cells produce.
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Cancer Therapies02:49

Cancer Therapies

Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
Cancer Therapies02:49

Cancer Therapies

Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...

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Related Experiment Video

Updated: Jun 1, 2026

Pretargeted Radioimmunotherapy Based on the Inverse Electron Demand Diels-Alder Reaction
09:44

Pretargeted Radioimmunotherapy Based on the Inverse Electron Demand Diels-Alder Reaction

Published on: January 29, 2019

Radioimmunotherapy: a brief overview.

Dce Ng1

  • 1Department of Nuclear Medicine and PET, Singapore General Hospital, Singapore.

Biomedical Imaging and Intervention Journal
|May 27, 2011
PubMed
Summary
This summary is machine-generated.

Radioimmunotherapy (RIT) is a promising cancer treatment, especially for non-Hodgkin's lymphoma, utilizing targeted antibodies and radiation. Ongoing research explores new applications in blood cancers, solid tumors, and innovative treatment protocols.

Keywords:
Monoclonal antibodiesibritumomab tiuxetanoncologytositumomab

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Last Updated: Jun 1, 2026

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Area of Science:

  • Oncology
  • Nuclear Medicine
  • Biotechnology

Background:

  • Radioimmunotherapy (RIT) leverages advances in molecular and cellular biology for cancer treatment.
  • RIT has demonstrated clinical efficacy, particularly in treating non-Hodgkin's lymphomas.

Purpose of the Study:

  • To survey the fundamental science of RIT.
  • To review monoclonal antibodies and radionuclides employed in RIT.
  • To examine the clinical applications and future directions of RIT.

Main Methods:

  • Review of basic RIT science.
  • Survey of monoclonal antibodies and radionuclides.
  • Literature review of clinical RIT applications.

Main Results:

  • RIT is an established oncologic therapeutic modality.
  • Non-Hodgkin's lymphoma is a key area of RIT efficacy.
  • New research indicates potential for hematological and solid-organ RIT.

Conclusions:

  • RIT shows significant promise in oncology.
  • Further development in radionuclides and clinical protocols is anticipated.
  • RIT holds potential for expanded therapeutic applications.