Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Positron Emission Tomography

Positron Emission Tomography

Positron emission tomography (PET) is a medical imaging technique involving radiopharmaceuticals — substances that emit short-lived radiation. Although the first PET scanner was introduced in 1961, it took 15 more years before radiopharmaceuticals were combined with the technique and revolutionized its potential.
One of the main requirements of a PET scan is a positron-emitting radioisotope, which is produced in a cyclotron and then attached to a substance used by the part of the body being...

Imaging Studies II: Positron Emission Tomography and Scintigraphy

Imaging Studies II: Positron Emission Tomography and Scintigraphy

Positron Emission Tomography (PET) is a medical imaging technique that provides crucial insights into the body's physiological functions at a molecular level. It is an indispensable resource for diagnosing, staging, and monitoring various illnesses, notably cancer, neurological disorders, and cardiovascular conditions.
Fundamental Principles of PET

Radiological Investigation III: Pulmonary Angiogram and PET Scan

Radiological Investigation III: Pulmonary Angiogram and PET Scan

Radiological investigations are paramount in the diagnosis and management of various pulmonary diseases. Two essential investigations are the Pulmonary Angiogram and the Positron Emission Tomography (PET) Scan.
Pulmonary Angiogram
A Pulmonary Angiogram is an invasive procedure involving injecting a contrast medium through a catheter threaded into the pulmonary artery or the right side of the heart to visualize the pulmonary vasculature. Computed Tomography (CT) scans have mainly replaced this...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Imaging features of fungal infection in immuno-suppressed patients in a local ward outbreak.

Biomedical imaging and intervention journal·2011

Same author

Osteosarcoma of the rib.

Biomedical imaging and intervention journal·2011

Same author

Malignant epignathus teratoma.

Biomedical imaging and intervention journal·2011

Same author

Chest imaging features of patients afflicted with Influenza A (H1N1) in a Malaysian tertiary referral centre.

Biomedical imaging and intervention journal·2011

Search research articles

Related Experiment Video

Updated: Jun 1, 2026

Management of Respiratory Motion Artefacts in 18F-fluorodeoxyglucose Positron Emission Tomography using an Amplitude-Based Optimal Respiratory Gating Algorithm

Management of Respiratory Motion Artefacts in ¹⁸F-fluorodeoxyglucose Positron Emission Tomography using an Amplitude-Based Optimal Respiratory Gating Algorithm

Published on: July 23, 2020

Physiological uptake in FDG PET simulating disease.

S Ahmad Sarji¹

¹Department of Biomedical Imaging, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.

Biomedical Imaging and Intervention Journal

|May 27, 2011

Summary

F-18 fluorodeoxyglucose (FDG) PET imaging has many pitfalls due to normal FDG uptake. Using PET CT imaging can help, but also introduces new challenges like misregistration artifacts.

Keywords:

FDG PET artefacts physiological uptake pitfalls

More Related Videos

Radiotracer Administration for High Temporal Resolution Positron Emission Tomography of the Human Brain: Application to FDG-fPET

Radiotracer Administration for High Temporal Resolution Positron Emission Tomography of the Human Brain: Application to FDG-fPET

Published on: October 22, 2019

Utilizing 18F-FDG PET/CT Imaging and Quantitative Histology to Measure Dynamic Changes in the Glucose Metabolism in Mouse Models of Lung Cancer

Utilizing ¹⁸F-FDG PET/CT Imaging and Quantitative Histology to Measure Dynamic Changes in the Glucose Metabolism in Mouse Models of Lung Cancer

Published on: July 21, 2018

Related Experiment Videos

Last Updated: Jun 1, 2026

Management of Respiratory Motion Artefacts in 18F-fluorodeoxyglucose Positron Emission Tomography using an Amplitude-Based Optimal Respiratory Gating Algorithm

Management of Respiratory Motion Artefacts in ¹⁸F-fluorodeoxyglucose Positron Emission Tomography using an Amplitude-Based Optimal Respiratory Gating Algorithm

Published on: July 23, 2020

Radiotracer Administration for High Temporal Resolution Positron Emission Tomography of the Human Brain: Application to FDG-fPET

Radiotracer Administration for High Temporal Resolution Positron Emission Tomography of the Human Brain: Application to FDG-fPET

Published on: October 22, 2019

Utilizing 18F-FDG PET/CT Imaging and Quantitative Histology to Measure Dynamic Changes in the Glucose Metabolism in Mouse Models of Lung Cancer

Utilizing ¹⁸F-FDG PET/CT Imaging and Quantitative Histology to Measure Dynamic Changes in the Glucose Metabolism in Mouse Models of Lung Cancer

Published on: July 21, 2018

Area of Science:

Nuclear Medicine
Radiology
Medical Imaging

Background:

F-18 fluorodeoxyglucose (FDG) Positron Emission Tomography (PET) imaging is widely used, particularly in oncology.
Numerous potential pitfalls and artifacts can arise during FDG PET interpretation, often due to normal physiological FDG uptake in various body sites.
Misinterpreting normal uptake or benign FDG-avid processes can lead to diagnostic errors.

Purpose of the Study:

To review common pitfalls and artifacts in FDG PET imaging.
To highlight the importance of clinical correlation and knowledge of normal FDG distribution.
To discuss the role and limitations of combined PET CT imaging in addressing these challenges.

Main Methods:

Review of literature on FDG PET imaging artifacts and normal variants.
Discussion of strategies for patient preparation to minimize artifacts.
Analysis of the benefits and drawbacks of integrated PET CT technology.

Main Results:

Normal FDG uptake in various organs can mimic pathology, especially in cancer imaging.
PET CT imaging aids in localizing FDG activity to anatomical structures seen on CT, improving interpretation.
Combined PET CT introduces new artifacts, including respiratory misregistration and overestimation of activity due to high-density materials affecting attenuation correction.

Conclusions:

Thorough understanding of normal FDG distribution and patient preparation are crucial for accurate FDG PET interpretation.
While PET CT enhances anatomical localization, awareness of its specific artifacts is necessary for reliable diagnosis.
Continuous vigilance and knowledge of imaging techniques are essential to overcome challenges in FDG PET/CT interpretation.