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Related Concept Videos

Circadian Rhythms and Gene Regulation02:19

Circadian Rhythms and Gene Regulation

The biological clock is involved in many aspects of regulating complex physiology in all animals. It was in 1935 when German zoologists, Hans Kalmus and Erwin Bünning, discovered the existence of circadian rhythm in Drosophila melanogaster. However, the internal molecular mechanisms behind the circadian clock remained a mystery until 1984, when Jeffrey C. Hall, Michael Rosbash, and Michael W. Young discovered the expression of the Per gene oscillating over a 24-hour cycle. In subsequent years,...
Circadian Rhythms and Gene Regulation02:19

Circadian Rhythms and Gene Regulation

The biological clock is involved in many aspects of regulating complex physiology in all animals. It was in 1935 when German zoologists, Hans Kalmus and Erwin Bünning, discovered the existence of circadian rhythm in Drosophila melanogaster. However, the internal molecular mechanisms behind the circadian clock remained a mystery until 1984, when Jeffrey C. Hall, Michael Rosbash, and Michael W. Young discovered the expression of the Per gene oscillating over a 24-hour cycle. In subsequent years,...
Chronopharmacokinetics: Circadian Rhythms and Influence on Drug Response01:15

Chronopharmacokinetics: Circadian Rhythms and Influence on Drug Response

Circadian rhythms are cyclic changes that are crucial in plasma drug concentrations. Various standard circadian parameters, including core body temperature, heart rate, and other cardiovascular factors, directly impact disease states and the therapeutic response to drug therapy.
The time of drug administration is an important factor to consider, as it can influence the toxic dose of a drug. For example, a study conducted by Prins et al. in 1997 examined the effects of the timing of...
Biological Clocks and Seasonal Responses02:45

Biological Clocks and Seasonal Responses

The circadian—or biological—clock is an intrinsic, timekeeping, molecular mechanism that allows plants to coordinate physiological activities over 24-hour cycles called circadian rhythms. Photoperiodism is a collective term for the biological responses of plants to variations in the relative lengths of dark and light periods. The period of light-exposure is called the photoperiod.
Restless Leg Syndrome and Night Terrors01:27

Restless Leg Syndrome and Night Terrors

Restless Leg Syndrome (RLS), also known as Willis-Ekbom disease, is a neurological disorder characterized by an uncontrollable urge to move the legs due to uncomfortable sensations. These sensations typically occur during periods of rest or inactivity, particularly when lying down or sitting, and can severely disrupt sleep.
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Sleep-Wake Cycles01:24

Sleep-Wake Cycles

Sleep is an essential physiological process vital to maintaining overall well-being. The reticular activating system (RAS), a network of neurons in the brainstem, regulates wakefulness and sleep. While it may seem passive, sleep consists of distinct cycles, each with its unique characteristics and functions. Two key sleep phases are non-rapid eye movement (NREM) and  rapid eye movement (REM).
NREM Sleep
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The Use of Mouse Splenocytes to Assess Pathogen-associated Molecular Pattern Influence on Clock Gene Expression
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[Rheumatism, jet lag and the body clock].

G Pongratz1, R H Straub

  • 1Labor für experimentelle Rheumatologie und Neuroendokrinoimmunologie, Klinik und Poliklinik für Innere Medizin I, Universitätsklinikum Regensburg, Franz-Josef-Strauß-Allee 11, 93042, Regensburg, Deutschland. georg.pongratz@klinik.uni-regensburg.de

Zeitschrift Fur Rheumatologie
|May 27, 2011
PubMed
Summary

Circadian rhythms influence immune activity and rheumatic symptoms. Transmeridian travel causes jet lag, impacting individuals with rheumatic disorders, necessitating strategies to mitigate these effects.

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Last Updated: Jun 1, 2026

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Area of Science:

  • Chronobiology and immunology
  • Physiology and chronobiology
  • Rheumatology and chronobiology

Context:

  • Circadian rhythms regulate daily bodily functions, including immune system activity.
  • Immune system variability influences the intensity of rheumatic symptoms, such as morning stiffness.
  • External time cues (zeitgebers) like light, food, and activity synchronize circadian rhythms.

Purpose:

  • To discuss the impact of acute circadian phase shifts from transmeridian travel on rheumatic disorders.
  • To explore strategies for preventing jet lag in individuals with rheumatic conditions.

Summary:

  • Acute shifts in external time cues, such as during transmeridian travel, disrupt circadian systems.
  • This disruption leads to an adjustment period characterized by jet lag symptoms like fatigue and cognitive issues.
  • The article examines how these shifts affect individuals with rheumatic disorders.

Impact:

  • Understanding circadian rhythm disruption is crucial for managing rheumatic symptoms during travel.
  • Developing preventative strategies for jet lag can improve the well-being of travelers with rheumatic conditions.
  • This research highlights the interplay between chronobiology, immunity, and rheumatic disease management.