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Updated: Jun 1, 2026
06:50
The Use of Mouse Splenocytes to Assess Pathogen-associated Molecular Pattern Influence on Clock Gene Expression
Published on: July 24, 2018
[Rheumatism, jet lag and the body clock]
1Labor für experimentelle Rheumatologie und Neuroendokrinoimmunologie, Klinik und Poliklinik für Innere Medizin I, Universitätsklinikum Regensburg, Franz-Josef-Strauß-Allee 11, 93042, Regensburg, Deutschland. georg.pongratz@klinik.uni-regensburg.de
Zeitschrift Fur Rheumatologie
|May 27, 2011
Summary
Circadian rhythms influence immune activity and rheumatic symptoms. Transmeridian travel causes jet lag, impacting individuals with rheumatic disorders, necessitating strategies to mitigate these effects.
Area of Science:
- Chronobiology and immunology
- Physiology and chronobiology
- Rheumatology and chronobiology
Context:
- Circadian rhythms regulate daily bodily functions, including immune system activity.
- Immune system variability influences the intensity of rheumatic symptoms, such as morning stiffness.
- External time cues (zeitgebers) like light, food, and activity synchronize circadian rhythms.
Purpose:
- To discuss the impact of acute circadian phase shifts from transmeridian travel on rheumatic disorders.
- To explore strategies for preventing jet lag in individuals with rheumatic conditions.
Summary:
- Acute shifts in external time cues, such as during transmeridian travel, disrupt circadian systems.
- This disruption leads to an adjustment period characterized by jet lag symptoms like fatigue and cognitive issues.
- The article examines how these shifts affect individuals with rheumatic disorders.
Impact:
- Understanding circadian rhythm disruption is crucial for managing rheumatic symptoms during travel.
- Developing preventative strategies for jet lag can improve the well-being of travelers with rheumatic conditions.
- This research highlights the interplay between chronobiology, immunity, and rheumatic disease management.
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