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Environmental risk factors in pediatric psoriasis: a multicenter case-control study

Müge G Ozden1, Nilgün S Tekin, Mehmet A Gürer

  • 1Dermatology Department, Medical Faculty, Ondokuz Mayis University, Samsun, Turkey. mgulerozden@hotmail.com

Pediatric Dermatology
|May 28, 2011
PubMed

Insights

Environmental tobacco smoke exposure, stressful life events, and high body mass index (BMI) are linked to childhood-onset psoriasis. These factors may influence the development of pediatric psoriasis in children.

Area of Science:

  • Dermatology
  • Pediatrics
  • Epidemiology

Background:

  • Childhood-onset psoriasis is a chronic inflammatory skin condition.
  • Identifying risk factors for pediatric psoriasis is crucial for early intervention.

Purpose of the Study:

  • To investigate potential risk factors, including breastfeeding, associated with the development of childhood-onset psoriasis.
  • To analyze the influence of environmental factors and lifestyle on pediatric psoriasis incidence.

Main Methods:

  • A multicenter case-control study with prospective data collection was conducted.
  • Data on family history, environmental exposures, BMI, breastfeeding, and life events were collected from 537 pediatric psoriasis patients and 511 controls.
  • Standardized questionnaires were utilized for data acquisition.

Main Results:

  • Children with psoriasis showed higher exposure to environmental tobacco smoke at home and experienced more stressful life events.
  • Increased odds ratios (OR) were observed for smoking (2.90) and stressful life events (2.94).
  • Higher body mass index (BMI > 26) was also associated with pediatric psoriasis (OR=2.52).

Conclusions:

  • Environmental tobacco smoke exposure, stressful life events, and high BMI are significant risk factors for childhood-onset psoriasis.
  • These factors may play a role in the pathogenesis of pediatric psoriasis.
  • Breastfeeding, cow's milk intake, and delivery method were not significantly associated with pediatric psoriasis in this study.

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