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Related Experiment Video

Updated: Jun 1, 2026

Novel In Vivo Micro-Computed Tomography Imaging Techniques for Assessing the Progression of Non-Alcoholic Fatty Liver Disease

Novel In Vivo Micro-Computed Tomography Imaging Techniques for Assessing the Progression of Non-Alcoholic Fatty Liver Disease

Published on: March 24, 2023

Low-dose hepatic computed tomography perfusion imaging and its preliminary study.

Wen Jing Wang¹, Liang Zhong, Xiao Lan Hua

¹Department of Radiology, Renji Hospital, Shanghai Jiaotong University School of Medicine, 145 Shandong Zhong Road, Shanghai, China.

Journal of Digestive Diseases

|May 28, 2011

Summary

Low-dose computed tomography perfusion imaging (CTPI) provides comparable liver hemodynamic data to conventional doses while significantly reducing radiation exposure. This method shows promise for diagnosing liver diseases like hepatocellular carcinoma (HCC).

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Novel In Vivo Micro-Computed Tomography Imaging Techniques for Assessing the Progression of Non-Alcoholic Fatty Liver Disease

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Published on: July 18, 2025

Area of Science:

Radiology and Imaging Science
Hepatology and Liver Disease Research

Background:

Computed tomography perfusion imaging (CTPI) assesses liver hemodynamics but is limited by high radiation dosage.
Hepatocellular carcinoma (HCC) and other liver diseases involve significant hemodynamic changes.
Reducing radiation exposure in CTPI is crucial for broader clinical adoption.

Purpose of the Study:

To evaluate the feasibility of low-dose CTPI in normal liver.
To assess the preliminary application of low-dose CTPI in diagnosing hepatocellular carcinoma (HCC).

Main Methods:

34 healthy volunteers underwent CTPI with conventional, median, and low radiation doses.
Perfusion parameters were compared across dose groups.
Low-dose CTPI was then applied to 13 patients diagnosed with HCC.

Main Results:

Satisfactory liver CTPI images and perfusion parameters were obtained at all tested radiation doses.
No significant differences in perfusion parameters were observed between the dose groups (P>0.05).
Low-dose CTPI reduced effective radiation dosage by 64.27% compared to conventional doses.
HCC patients showed elevated hepatic blood flow, hepatic blood volume, and hepatic perfusion index compared to normal liver parenchyma.

Conclusions:

Low-dose liver CTPI yields comparable perfusion parameter results to conventional-dose CTPI.
Radiation dosage is significantly reduced (by approximately 2/3) with low-dose CTPI.
Low-dose CTPI effectively reflects hemodynamic changes in HCC and holds potential for diagnosing liver diseases.