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A RAPID Method for Blood Processing to Increase the Yield of Plasma Peptide Levels in Human Blood
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A RAPID Method for Blood Processing to Increase the Yield of Plasma Peptide Levels in Human Blood

Published on: April 28, 2016

Ghrelin and cancer.

Lisa Chopin1, Carina Walpole, Inge Seim

  • 1Queensland University of Technology, Brisbane, Australia. l.chopin@qut.edu.au

Molecular and Cellular Endocrinology
|May 28, 2011
PubMed
Summary

Ghrelin, a peptide hormone, regulates appetite and growth hormone release. It is also found in cancers, potentially influencing tumor progression, proliferation, and cell invasion.

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Published on: April 11, 2025

Area of Science:

  • Endocrinology
  • Molecular Biology
  • Oncology

Background:

  • Ghrelin is a peptide hormone originating in the stomach.
  • It acts as the endogenous ligand for the growth hormone secretagogue receptor (GHSR).
  • Ghrelin influences appetite, gut motility, growth hormone release, and cardiovascular and immune functions.

Purpose of the Study:

  • To investigate the role of ghrelin and its receptor in cancer.
  • To explore ghrelin's potential involvement in cancer progression.

Main Methods:

  • Expression analysis of ghrelin and GHSR in cancer tissues and cell lines.
  • Functional assays to assess ghrelin's impact on cancer cell proliferation, apoptosis, invasion, and migration.

Main Results:

  • Ghrelin and GHSR are expressed in various cancers and cell lines.
  • Ghrelin signaling may promote cancer progression through effects on cell proliferation, apoptosis, invasion, and migration.

Conclusions:

  • Ghrelin and its receptor are implicated in cancer development and progression.
  • Targeting the ghrelin system could offer novel therapeutic strategies for cancer treatment.