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Updated: Jun 1, 2026

The Subventricular Zone En-face: Wholemount Staining and Ependymal Flow
Published on: May 6, 2010
Subventricular zone in motor neuron disease with frontotemporal dementia
Lucia Galan1, Ulises Gomez-Pinedo, Alvaro Vela-Souto
1Neuromuscular Unit, Neurology Department, Hospital Clinico San Carlos, Madrid, Spain. elainvestigacion@luciagalan.es
Abstract:
Investigate how the subventricular proliferation and organisation is modified in a patient with FTLD-ALS. We studied the subventricular zone (SVZ) of a patient with FTLD-ALS immunohistochemical and histologically. We found an increase of Ki-67 positive cells and neuroblast in the subventricular zone, suggesting an activation of proliferating activity in response to FTD-ALS. This proliferation can act as a compensatory mechanism for rapid neuronal death and its modulation could provide a new therapeutic pathway in ALS. These results suggest a modification of neurogenesis in FTD-ALS.
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