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Tumor Progression02:07

Tumor Progression

Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Tumor Progression02:07

Tumor Progression

Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
The Tumor Microenvironment02:17

The Tumor Microenvironment

Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
The Tumor Microenvironment02:17

The Tumor Microenvironment

Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
Cancer02:18

Cancer

Cancers arise due to mutations in genes involved in the regulation of cell division, which leads to unrestricted cell proliferation. Modern science and medicine have made great strides in the understanding and treatment of cancer, including eradicating cancer in some patients. However, there is still no cure for cancer. This is largely due to the fact that cancer is a large group of many diseases.
mTOR Signaling and Cancer Progression03:03

mTOR Signaling and Cancer Progression

The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...

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Related Experiment Video

Updated: Jun 1, 2026

A Model for Perineural Invasion in Head and Neck Squamous Cell Carcinoma
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Published on: January 5, 2017

The neuronal influence on tumor progression.

Mario Mancino1, Elisabet Ametller, Pedro Gascón

  • 1Department of Medical Oncology, Centro Esther Koplowitz CEK, Institut d' investigacions Biomèdiques August Pi i Sunyer IDIBAPS, Hospital Clinic, Medical School, University of Barcelona, Barcelona, Spain.

Biochimica Et Biophysica Acta
|May 28, 2011
PubMed
Summary

Cancer cells interact with nerve fibers, influencing tumor growth and survival. Understanding this neurosignaling is key for developing new cancer therapies and prevention strategies.

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Area of Science:

  • Oncology
  • Neuroscience
  • Cancer Biology

Background:

  • Nerve fibers are present throughout the body, accompanying blood and lymphatic vessels.
  • While tumor angiogenesis and lymphangiogenesis are well-studied, the role of
  • neoneurogenesis
  • in cancer is less understood.
  • Cancer cells can leverage nerve-derived factors for survival and proliferation, and stimulate nerve growth.

Purpose of the Study:

  • To review the current understanding of neurosignaling in cancer.
  • To explore the biological effects of nerve-cancer cell interactions.
  • To discuss the implications for cancer prevention and therapy.

Main Methods:

  • Literature review of existing research on neurosignaling in cancer.
  • Analysis of experimental evidence demonstrating reciprocal interactions between cancer cells and nerves.
  • Focus on soluble factors released by cancer cells and nerve endings.

Main Results:

  • Increasing evidence supports reciprocal interactions between cancer cells and nerves in humans.
  • Cancer cells and nerve fibers engage in crosstalk for tumor survival.
  • The precise roles of neurotransmitters, neuropeptides, and signaling pathways in cancer progression require further clarification.

Conclusions:

  • Neurosignaling plays a significant role in cancer development, progression, and treatment response.
  • Characterizing tumor microenvironment neurotransmitters/neuropeptides can reveal neuronal influences on tumor biology.
  • Further research into neurosignaling pathways holds potential for novel cancer prevention and therapeutic strategies.