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Efficacy of acupuncture for migraine prophylaxis: a single-blinded, double-dummy, randomized controlled trial
Lin-Peng Wang1, Xiao-Zhe Zhang, Jia Guo
1Acupuncture and Moxibustion Department, Beijing Traditional Chinese Medicine Hospital affiliated with Capital Medical University, Beijing, China Acupuncture and Moxibustion Department, Beijing Tiantan Hospital affiliated with Capital Medical University, Beijing, China Acupuncture and Moxibustion Department, the Third Hospital of Peking University, Beijing, China Quintiles Medical Development (Shanghai) Co., Ltd. Beijing Branch, Beijing, China Acupuncture and Moxibustion Department, Huguosi Hospital affiliated with the Beijing University of Chinese Medicine, Beijing, China Acupuncture and Moxibustion Department, Dongzhimen Hospital affiliated with the Beijing University of Chinese Medicine, Beijing, China.
Abstract:
Insufficient clinical trial data were available to prove the efficacy of acupuncture for migraine prophylaxis. A multicenter, double-dummy, single-blinded, randomized controlled clinical trial was conducted at the outpatient departments of acupuncture at 5 hospitals in China to evaluate the effectiveness of acupuncture. A total of 140 patients with migraine without aura were recruited and assigned randomly to 2 different groups: the acupuncture group treated with verum acupuncture plus placebo and the control group treated with sham acupuncture plus flunarizine. Treated by acupuncture 3 times per week and drugs every night, patients from both groups were evaluated at week 0 (baseline), week 4, and week 16. The primary outcome was measured by the proportion of responders (defined as the proportion of patients with a reduction of migraine days by at least 50%). The secondary outcome measures included the number of migraine days, visual analogue scale (VAS, 0 to 10 cm) for pain, as well as the physical and mental component summary scores of the 36-item short-form health survey (SF-36). The patients in the acupuncture group had better responder rates and fewer migraine days compared with the control group (P<.05), whereas there were no significant differences between the 2 groups in VAS scores and SF-36 physical and mental component summary scores (P>.05). The results suggested that acupuncture was more effective than flunarizine in decreasing days of migraine attacks, whereas no significantly differences were found between acupuncture and flunarizine in reduction of pain intensity and improvement of the quality of life.