Related Experiment Video

Updated: Jun 1, 2026

A High-Throughput Multiplexed Screening for Type 1 Diabetes, Celiac Diseases, and COVID-19
06:46

A High-Throughput Multiplexed Screening for Type 1 Diabetes, Celiac Diseases, and COVID-19

Published on: July 5, 2022

The evaluation and management of childhood type 2 diabetes mellitus

Melissa Scollan-Koliopoulos1, Bleich David

  • 1Rutgers, The State University of New Jersey, College of Nursing, United States. scollame@umdnj.edu

Primary Care Diabetes
|May 28, 2011
PubMed

Insights

Childhood diabetes is rising, driven by obesity and insulin resistance. Tailored treatments focusing on obesity reduction, potentially using lipocentric approaches, are crucial for managing pediatric diabetes effectively.

Area of Science:

  • Pediatric Endocrinology
  • Metabolic Disorders
  • Public Health

Background:

  • Childhood diabetes prevalence is increasing globally.
  • Obesity-associated insulin resistance is a primary driver of pediatric diabetes.
  • Effective management requires addressing multifactorial causes and consequences.

Purpose of the Study:

  • To comprehensively review current treatment paradigms for pediatric diabetes.
  • To highlight the importance of tailored treatment plans.
  • To explore the role of obesity reduction in diabetes management.

Main Methods:

  • Extensive literature review on type 2 diabetes in children and adolescents.
  • Review focused on treatment strategies for pediatric diabetes and obesity.
  • Analysis of contributing factors and consequences of childhood diabetes.

Main Results:

  • Diabetes in children is rising, with obesity as a key factor.
  • Tailoring treatment plans is essential due to diverse contributing factors.
  • Obesity reduction should be a primary treatment outcome.
  • Lipocentric treatment paradigms show promise in mitigating obesity's impact.

Conclusions:

  • Pediatric diabetes management necessitates a multifaceted approach.
  • Reducing obesity is a critical goal in treating children with diabetes.
  • Lipocentric strategies may offer a novel therapeutic avenue for pediatric obesity and diabetes.

Related Concept Videos

Diabetes Mellitus: Type 2 and Gestational01:22

Diabetes Mellitus: Type 2 and Gestational

Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
Diabetes: Management and Pharmacotherapy01:15

Diabetes: Management and Pharmacotherapy

The therapy for diabetes aims to alleviate hyperglycemia-related symptoms, prevent acute metabolic decompensation, and reduce chronic end-organ complications. Glycemic control is evaluated through short-term (self-monitoring, continuous glucose monitoring) and long-term (A1c, fructosamine) metrics, enabling near real-time tracking of blood glucose levels and reflecting glycemic control over specific time frames.
Insulin remains the cornerstone of treatment for most patients with type 1 and many...
Type II Diabetes I: Introduction01:26

Type II Diabetes I: Introduction

Type 2 diabetes mellitus (T2DM) is a chronic metabolic disorder characterized by insulin resistance, in which target tissues such as the liver, muscle, and adipose tissue respond poorly to insulin. It is also associated with inadequate compensatory insulin secretion, where pancreatic β-cells fail to produce sufficient insulin. Together, these abnormalities lead to persistent hyperglycemia.EtiologyT2DM develops through a complex interaction of genetic predisposition and environmental or...
Diabetes Mellitus: Overview and Type I Subtype01:22

Diabetes Mellitus: Overview and Type I Subtype

Diabetes mellitus is a chronic metabolic disorder characterized by high blood glucose levels due to inadequate insulin production, insulin resistance, or both. The condition affects millions worldwide and can significantly impact their health and quality of life.
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
Type II Diabetes Mellitus III: Clinical Manifestations and Diagnosis01:25

Type II Diabetes Mellitus III: Clinical Manifestations and Diagnosis

Type 2 diabetes mellitus develops gradually and is often asymptomatic in early stages.Clinical ManifestationsWhen symptoms appear, they include fatigue, blurred vision, pruritus, delayed wound healing, and recurrent infections, particularly candidal infections. Peripheral neuropathy may present as numbness or tingling in the extremities. Classic hyperglycemia symptoms—polyuria, polydipsia, and polyphagia—are less common. Most patients are overweight and frequently have associated hypertension...
Type II Diabetes II: Pathophysiology01:24

Type II Diabetes II: Pathophysiology

PathophysiologyType 2 diabetes mellitus (T2DM ) is a chronic metabolic disorder characterized by insulin resistance and progressive pancreatic β-cell dysfunction, leading to impaired glucose homeostasis. It results from interactions among genetic predisposition, environmental factors, and metabolic stressors, such as overnutrition and a sedentary lifestyle.Insulin Resistance and Glucose DysregulationEarly T2DM involves insulin resistance in skeletal muscle, adipose tissue, and the liver.