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Post-exercise platelet activation--aggregation and release in relation to dynamic exercise.

O Naesh1, I Hindberg, J Trap-Jensen

  • 1Department of Clinical Physiology/Nuclear Medicine, Frederiksberg Hospital, Copenhagen, Denmark.

Clinical Physiology (Oxford, England)
|May 1, 1990
PubMed
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Moderate exercise activates human platelets, increasing release products like beta-thromboglobulin and serotonin post-workout. Platelet aggregability changes during and after exercise, indicating enhanced platelet activity in the recovery period.

Area of Science:

  • Exercise Physiology
  • Hematology
  • Human Physiology

Background:

  • Limited research exists on human platelet activity immediately following physical stress.
  • Previous studies noted increased platelet release products and hyperaggregability after surgical stress.

Purpose of the Study:

  • To investigate platelet function in healthy volunteers during and after submaximal cycle exercise.
  • To assess changes in platelet aggregability and plasma release products following moderate physical exertion.

Main Methods:

  • Eight healthy, non-medicated volunteers underwent cycle exercise of submaximal intensity.
  • Platelet function, including ADP- and adrenaline-induced aggregation, was measured during and 1 hour post-exercise.
  • Plasma levels of beta-thromboglobulin, serotonin, and cyclic AMP were analyzed.

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Main Results:

  • ADP-induced platelet aggregability increased during the final minute of exercise and decreased 1 hour post-exercise.
  • Adrenaline-induced platelet aggregation decreased post-exercise but showed no change during exercise.
  • Plasma beta-thromboglobulin and serotonin levels significantly increased after exercise, indicating enhanced platelet activity.

Conclusions:

  • Moderate exercise activates human platelets, evidenced by increased plasma release products post-exercise.
  • Platelet aggregability exhibits dynamic changes during and after physical activity.
  • The post-exercise period is crucial for understanding exercise-induced platelet activation and should be included in future research.