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Relationship between RANTES polymorphisms and respiratory syncytial virus bronchiolitis in a Japanese infant

Satoshi Hattori1, Naoki Shimojo, Toichi Mashimo

  • 1Department of Public Health, Chiba University Graduate School of Medicine, Chiba 260-8670, Japan.

Japanese Journal of Infectious Diseases
|May 28, 2011
PubMed

Insights

Genetic variations in the RANTES gene may influence the risk of severe respiratory syncytial virus (RSV) bronchiolitis in infants. Lower frequencies of specific RANTES genotypes and alleles were observed in infants with severe RSV bronchiolitis.

Area of Science:

  • Immunology
  • Genetics
  • Pediatrics

Background:

  • Respiratory syncytial virus (RSV) is a primary cause of infant bronchiolitis.
  • Regulated upon activation, normal T-cell expressed and secreted protein (RANTES, CCL5) is implicated in RSV-induced airway inflammation.

Purpose of the Study:

  • To investigate the association between RANTES gene single-nucleotide polymorphisms (SNPs) and the risk of severe RSV bronchiolitis in infants.

Main Methods:

  • Genotyping of three RANTES SNPs (-403G/A, -28C/G, In1.1T/C) was performed.
  • Case-control study comparing 59 infants with severe RSV bronchiolitis and 201 control subjects.

Main Results:

  • Significantly lower frequencies of genotypes -403G/A+A/A, -28C/G+G/G, and In1.1T/C+C/C were found in RSV bronchiolitis patients.
  • Allele frequencies of -403A, -28G, and In1.1C were significantly lower in the RSV patient group compared to controls.

Conclusions:

  • RANTES gene polymorphisms may be associated with an altered risk of developing severe RSV bronchiolitis.
  • These findings suggest a potential genetic predisposition to severe RSV infection in infants.

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